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The Relation of Dietary Vitamin C Intake to Bone Mineral Density: Results from the PEPI Study

Overview of attention for article published in Calcified Tissue International, September 1998
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

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1 policy source
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1 patent
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1 YouTube creator

Citations

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83 Mendeley
Title
The Relation of Dietary Vitamin C Intake to Bone Mineral Density: Results from the PEPI Study
Published in
Calcified Tissue International, September 1998
DOI 10.1007/s002239900512
Pubmed ID
Authors

S. L. Hall, G. A. Greendale

Abstract

Ascorbic acid is a required cofactor in the hydroxylations of lysine and proline necessary for collagen formation; its role in bone cell differentiation and formation is less well characterized. This study examines the cross-sectional relation between dietary vitamin C intake and bone mineral density (BMD) in women from the Postmenopausal Estrogen/Progestin Interventions Trial. BMD (spine and hip) was measured using dual energy X-ray absorptiometry (DXA). The PEPI participants (n = 775) included in this analysis were Caucasian and ranged in age from 45 to 64 years. At the femoral neck and total hip after adjustment for age, BMI, estrogen use, smoking, leisure physical activity, calcium and total energy intake, each 100 mg increment in dietary vitamin C intake, was associated with a 0. 017 g/cm2 increment in BMD (P = 0.002 femoral neck; P = 0.005 total hip). After adjustment, the association of vitamin C with lumbar spine BMD was similar to that at the hip, but was not statistically significant (P = 0.08). To assess for effect modification by dietary calcium, the analyses were repeated, stratified by calcium intake (>500 mg/day and </=500 mg/day). For the femoral neck, women with higher calcium intake had an increment of 0.0190 g/cm2 in BMD per 100 mg vitamin C (P = 0.002). No relation between BMD and vitamin C was evident in the lower calcium stratum. Similar effect modification by calcium was observed at the total hip: the beta coefficient in the higher calcium stratum was similar to that for the total sample (beta = 0.0172, P = 0.01), but no statistically significant relation between total hip BMD and vitamin C was found in the lower calcium subgroup. Although the relation between vitamin C and lumbar spine BMD was of marginal statistical significance in the total sample, among women ingesting higher calcium, a statistically significant association was observed (beta = 0.0199, P = 0.024). These data are consistent with a positive association of vitamin C with BMD in postmenopausal women with dietary calcium intakes of at least 500 mg.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 82 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 14%
Researcher 11 13%
Student > Ph. D. Student 8 10%
Student > Bachelor 7 8%
Other 5 6%
Other 16 19%
Unknown 24 29%
Readers by discipline Count As %
Medicine and Dentistry 13 16%
Nursing and Health Professions 11 13%
Agricultural and Biological Sciences 10 12%
Biochemistry, Genetics and Molecular Biology 9 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 8 10%
Unknown 29 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2021.
All research outputs
#4,899,699
of 23,803,958 outputs
Outputs from Calcified Tissue International
#308
of 1,819 outputs
Outputs of similar age
#4,548
of 32,730 outputs
Outputs of similar age from Calcified Tissue International
#1
of 9 outputs
Altmetric has tracked 23,803,958 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,819 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 32,730 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them