| Title |
Current knowledge on exosome biogenesis and release
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, July 2017
|
| DOI | 10.1007/s00018-017-2595-9 |
| Pubmed ID | |
| Authors |
Nina Pettersen Hessvik, Alicia Llorente |
| Abstract |
Exosomes are nanosized membrane vesicles released by fusion of an organelle of the endocytic pathway, the multivesicular body, with the plasma membrane. This process was discovered more than 30 years ago, and during these years, exosomes have gone from being considered as cellular waste disposal to mediate a novel mechanism of cell-to-cell communication. The exponential interest in exosomes experienced during recent years is due to their important roles in health and disease and to their potential clinical application in therapy and diagnosis. However, important aspects of the biology of exosomes remain unknown. To explore the use of exosomes in the clinic, it is essential that the basic molecular mechanisms behind the transport and function of these vesicles are better understood. We have here summarized what is presently known about how exosomes are formed and released by cells. Moreover, other cellular processes related to exosome biogenesis and release, such as autophagy and lysosomal exocytosis are presented. Finally, methodological aspects related to exosome release studies are discussed. |
X Demographics
The data shown below were collected from the profiles of 58 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 8 | 14% |
| United States | 3 | 5% |
| Chile | 3 | 5% |
| Uruguay | 1 | 2% |
| Venezuela, Bolivarian Republic of | 1 | 2% |
| Russia | 1 | 2% |
| Guinea-Bissau | 1 | 2% |
| Mexico | 1 | 2% |
| Ecuador | 1 | 2% |
| Other | 5 | 9% |
| Unknown | 33 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 56 | 97% |
| Scientists | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 2,003 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2003 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 353 | 18% |
| Student > Bachelor | 268 | 13% |
| Student > Master | 255 | 13% |
| Researcher | 203 | 10% |
| Student > Doctoral Student | 107 | 5% |
| Other | 213 | 11% |
| Unknown | 604 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 580 | 29% |
| Agricultural and Biological Sciences | 171 | 9% |
| Medicine and Dentistry | 148 | 7% |
| Immunology and Microbiology | 83 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 75 | 4% |
| Other | 285 | 14% |
| Unknown | 661 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2023.
All research outputs
#715,461
of 25,888,937 outputs
Outputs from Cellular and Molecular Life Sciences
#53
of 5,959 outputs
Outputs of similar age
#14,527
of 328,966 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#1
of 69 outputs
Altmetric has tracked 25,888,937 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,959 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,966 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.