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Pericytes Extend Survival of ALS SOD1 Mice and Induce the Expression of Antioxidant Enzymes in the Murine Model and in IPSCs Derived Neuronal Cells from an ALS Patient

Overview of attention for article published in Stem Cell Reviews, July 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#22 of 489)
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
1 news outlet
twitter
4 tweeters

Citations

dimensions_citation
26 Dimensions

Readers on

mendeley
22 Mendeley
Title
Pericytes Extend Survival of ALS SOD1 Mice and Induce the Expression of Antioxidant Enzymes in the Murine Model and in IPSCs Derived Neuronal Cells from an ALS Patient
Published in
Stem Cell Reviews, July 2017
DOI 10.1007/s12015-017-9752-2
Pubmed ID
Authors

Giuliana Castello Coatti, Miriam Frangini, Marcos C. Valadares, Juliana Plat Gomes, Natalia O. Lima, Natale Cavaçana, Amanda F. Assoni, Mayra V. Pelatti, Alexander Birbrair, Antonio Carlos Pedroso de Lima, Julio M. Singer, Francisco Marcelo M. Rocha, Giovani Loiola Da Silva, Mario Sergio Mantovani, Lucia Inês Macedo-Souza, Merari F. R. Ferrari, Mayana Zatz, Coatti, Giuliana Castello, Frangini, Miriam, Valadares, Marcos C., Gomes, Juliana Plat, Lima, Natalia O., Cavaçana, Natale, Assoni, Amanda F., Pelatti, Mayra V., Birbrair, Alexander, de Lima, Antonio Carlos Pedroso, Singer, Julio M., Rocha, Francisco Marcelo M., Da Silva, Giovani Loiola, Mantovani, Mario Sergio, Macedo-Souza, Lucia Inês, Ferrari, Merari F. R., Zatz, Mayana

Abstract

Amyotrophic Lateral Sclerosis (ALS) is one of the most common adult-onset motor neuron disease causing a progressive, rapid and irreversible degeneration of motor neurons in the cortex, brain stem and spinal cord. No effective treatment is available and cell therapy clinical trials are currently being tested in ALS affected patients. It is well known that in ALS patients, approximately 50% of pericytes from the spinal cord barrier are lost. In the central nervous system, pericytes act in the formation and maintenance of the blood-brain barrier, a natural defense that slows the progression of symptoms in neurodegenerative diseases. Here we evaluated, for the first time, the therapeutic effect of human pericytes in vivo in SOD1 mice and in vitro in motor neurons and other neuronal cells derived from one ALS patient. Pericytes and mesenchymal stromal cells (MSCs) were derived from the same adipose tissue sample and were administered to SOD1 mice intraperitoneally. The effect of the two treatments was compared. Treatment with pericytes extended significantly animals survival in SOD1 males, but not in females that usually have a milder phenotype with higher survival rates. No significant differences were observed in the survival of mice treated with MSCs. Gene expression analysis in brain and spinal cord of end-stage animals showed that treatment with pericytes can stimulate the host antioxidant system. Additionally, pericytes induced the expression of SOD1 and CAT in motor neurons and other neuronal cells derived from one ALS patient carrying a mutation in FUS. Overall, treatment with pericytes was more effective than treatment with MSCs. Our results encourage further investigations and suggest that pericytes may be a good option for ALS treatment in the future. Graphical Abstract ᅟ.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 5 23%
Student > Postgraduate 4 18%
Student > Doctoral Student 3 14%
Researcher 3 14%
Student > Ph. D. Student 2 9%
Other 5 23%
Readers by discipline Count As %
Unspecified 8 36%
Biochemistry, Genetics and Molecular Biology 5 23%
Agricultural and Biological Sciences 4 18%
Medicine and Dentistry 2 9%
Decision Sciences 1 5%
Other 2 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2018.
All research outputs
#1,409,138
of 13,157,264 outputs
Outputs from Stem Cell Reviews
#22
of 489 outputs
Outputs of similar age
#45,144
of 264,329 outputs
Outputs of similar age from Stem Cell Reviews
#1
of 17 outputs
Altmetric has tracked 13,157,264 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 489 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,329 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.