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Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis

Overview of attention for article published in Brain Structure & Function, December 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 1,001)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
21 news outlets
blogs
3 blogs
twitter
39 tweeters
facebook
5 Facebook pages
googleplus
1 Google+ user
reddit
1 Redditor
video
3 video uploaders

Citations

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17 Dimensions

Readers on

mendeley
69 Mendeley
Title
Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis
Published in
Brain Structure & Function, December 2013
DOI 10.1007/s00429-013-0679-3
Pubmed ID
Authors

Imke Kirste, Zeina Nicola, Golo Kronenberg, Tara L. Walker, Robert C. Liu, Gerd Kempermann

Abstract

We have previously hypothesized that the reason why physical activity increases precursor cell proliferation in adult neurogenesis is that movement serves as non-specific signal to evoke the alertness required to meet cognitive demands. Thereby a pool of immature neurons is generated that are potentially recruitable by subsequent cognitive stimuli. Along these lines, we here tested whether auditory stimuli might exert a similar non-specific effect on adult neurogenesis in mice. We used the standard noise level in the animal facility as baseline and compared this condition to white noise, pup calls, and silence. In addition, as patterned auditory stimulus without ethological relevance to mice we used piano music by Mozart (KV 448). All stimuli were transposed to the frequency range of C57BL/6 and hearing was objectified with acoustic evoked potentials. We found that except for white noise all stimuli, including silence, increased precursor cell proliferation (assessed 24 h after labeling with bromodeoxyuridine, BrdU). This could be explained by significant increases in BrdU-labeled Sox2-positive cells (type-1/2a). But after 7 days, only silence remained associated with increased numbers of BrdU-labeled cells. Compared to controls at this stage, exposure to silence had generated significantly increased numbers of BrdU/NeuN-labeled neurons. Our results indicate that the unnatural absence of auditory input as well as spectrotemporally rich albeit ethological irrelevant stimuli activate precursor cells-in the case of silence also leading to greater numbers of newborn immature neurons-whereas ambient and unstructured background auditory stimuli do not.

Twitter Demographics

The data shown below were collected from the profiles of 39 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Germany 1 1%
Denmark 1 1%
Unknown 66 96%

Demographic breakdown

Readers by professional status Count As %
Unspecified 16 23%
Student > Ph. D. Student 13 19%
Student > Bachelor 8 12%
Student > Master 8 12%
Researcher 6 9%
Other 18 26%
Readers by discipline Count As %
Unspecified 19 28%
Agricultural and Biological Sciences 11 16%
Neuroscience 11 16%
Medicine and Dentistry 10 14%
Psychology 7 10%
Other 11 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 231. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2019.
All research outputs
#56,186
of 13,640,261 outputs
Outputs from Brain Structure & Function
#3
of 1,001 outputs
Outputs of similar age
#811
of 188,009 outputs
Outputs of similar age from Brain Structure & Function
#1
of 12 outputs
Altmetric has tracked 13,640,261 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,001 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,009 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.