Title |
The Tumor Entity Denominated “clear cell-papillary renal cell carcinoma” According to the WHO 2016 new Classification, have the Clinical Characters of a Renal Cell Adenoma as does Harbor a Benign Outcome
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Published in |
Pathology & Oncology Research, July 2017
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DOI | 10.1007/s12253-017-0271-x |
Pubmed ID | |
Authors |
Francesco Massari, Chiara Ciccarese, Ondrej Hes, Michal Michal, Anna Caliò, Michelangelo Fiorentino, Francesca Giunchi, Alessandro D’Amuri, Francesca Sanguedolce, Roberto Sabbatini, Annalisa Guida, Andrea Ardizzoni, Camillo Porta, Roberto Iacovelli, Giampaolo Tortora, Luca Cima, Cinzia Ortega, Alberto Lapini, Guido Martignoni, Matteo Brunelli |
Abstract |
The new WHO 2016 classification of renal neoplasia encounters the new entity called "clear cell papillary renal cell carcinoma" (ccpRCC). The ccpRCC has been long included as a subtype of clear cell RCC histotype and it actually ranges from 2 to 9% in different routinely available cohort of renal carcinomas. Of important note, ccpRCC does not show any recurrences or metastases or lymph-node invasion and the outcome is always good. We reviewed twenty-four publications with available follow-up for patients (no. 362) affected by clear cell papillary RCCs/renal adenomatoid tumours and notably ccpRCC harbors an indolent clinical behavior after a mean of 38 months (3,5 years) of follow-up. This paper reviews the histological, molecular and clinical features characterizing ccpRCC, with the goal of focusing the knowledge of the benign fashion of this new tumour entity, supporting the idea of a new renal cell adenoma recruited morphologically from ex conventional clear cell RCC tumours. |
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China | 1 | 10% |
Ecuador | 1 | 10% |
Spain | 1 | 10% |
Unknown | 5 | 50% |
Demographic breakdown
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Practitioners (doctors, other healthcare professionals) | 3 | 30% |
Science communicators (journalists, bloggers, editors) | 2 | 20% |
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Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 6 | 24% |
Student > Postgraduate | 3 | 12% |
Professor > Associate Professor | 3 | 12% |
Student > Master | 3 | 12% |
Researcher | 2 | 8% |
Other | 4 | 16% |
Unknown | 4 | 16% |
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Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Psychology | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Unknown | 7 | 28% |