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Outcome of patients with septic shock and high-dose vasopressor therapy

Overview of attention for article published in Annals of Intensive Care, April 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

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2 blogs
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6 X users
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1 Wikipedia page

Citations

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98 Dimensions

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129 Mendeley
Title
Outcome of patients with septic shock and high-dose vasopressor therapy
Published in
Annals of Intensive Care, April 2017
DOI 10.1186/s13613-017-0261-x
Pubmed ID
Authors

Thomas Auchet, Marie-Alix Regnier, Nicolas Girerd, Bruno Levy

Abstract

Despite the dissemination of international guidelines, mortality from septic shock remains high. Norepinephrine is recommended as first-line vasopressor therapy with a target mean arterial pressure of 65 mmHg. High-dose vasopressor (HDV) may also be required. This study aimed to assess survival in patients with septic shock requiring HDV. We conducted a retrospective study of patients admitted between January 2008 and December 2013 to a 13-bed ICU for septic shock and receiving high-dose vasopressor therapy (defined by a dose >1 µg/kg/min). Primary outcome was 28-day mortality (D28). Secondary outcomes were 90-day mortality (D90), organ failure score (SOFA), duration of organ failure, duration and dosage of vasopressor agent and ischemic complications. In our cohort of 106 patients, mortality reached 60.4% at D28 and 66.3% at D90. One in two patients died before D10. The weight-based mean dose of vasopressor (WMD) represented the best prognostic factor. Using a cutoff of 0.75 µg/kg/min, WMD was associated with mortality with a sensitivity of 73% and specificity of 74%. The mortality rate reached 86.4% when WMD was above the cutoff value and associated with a SOFA score >10. Digital or limb necrosis was documented in 6 patients (5.7%). In total, 40% of septic shock patients receiving high-dose vasopressor therapy survived at day 28 after admission. A WMD cutoff value of 0.75 µg/kg/min, associated with a >10 SOFA score, was a strong predictor of death. These results provide insights into outcome of refractory septic shock, showing that administration of high-dose vasopressor may indeed be useful in these patients.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 <1%
Unknown 128 99%

Demographic breakdown

Readers by professional status Count As %
Other 13 10%
Researcher 12 9%
Student > Doctoral Student 11 9%
Student > Ph. D. Student 10 8%
Student > Postgraduate 10 8%
Other 28 22%
Unknown 45 35%
Readers by discipline Count As %
Medicine and Dentistry 57 44%
Nursing and Health Professions 5 4%
Pharmacology, Toxicology and Pharmaceutical Science 3 2%
Unspecified 3 2%
Computer Science 2 2%
Other 11 9%
Unknown 48 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2023.
All research outputs
#1,787,522
of 24,873,243 outputs
Outputs from Annals of Intensive Care
#217
of 1,151 outputs
Outputs of similar age
#33,936
of 315,502 outputs
Outputs of similar age from Annals of Intensive Care
#6
of 26 outputs
Altmetric has tracked 24,873,243 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,151 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.4. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,502 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.