| Title |
Emergence of antimicrobial resistance to Pseudomonas aeruginosa in the intensive care unit: association with the duration of antibiotic exposure and mode of administration
|
|---|---|
| Published in |
Annals of Intensive Care, June 2017
|
| DOI | 10.1186/s13613-017-0296-z |
| Pubmed ID | |
| Authors |
Erlangga Yusuf, Bruno Van Herendael, Walter Verbrugghe, Margareta Ieven, Emiel Goovaerts, Kristof Bergs, Kristien Wouters, Philippe G. Jorens, Herman Goossens |
| Abstract |
Antibiotics are frequently used in intensive care units (ICUs), and their use is associated with the emergence of bacterial resistance to antibiotics. The aim of this study was to investigate the association between the emergence of Pseudomonas aeruginosa resistance and the duration of antibiotic exposure or mode of administration in an ICU unit. A 4-year cohort study of intensive care unit was performed in patients with P. aeruginosa isolates from clinical specimens, initially susceptible to the investigated antibiotics (piperacillin/tazobactam, ceftazidime, ciprofloxacin, meropenem and amikacin). Odds ratios (ORs) with 95% confidence interval (95% CI) of emergence of resistance were calculated using logistic regression analysis for various exposure periods to antibiotics (1-3, 4-7, 8-15 and >15 days) relative to no exposure with adjustment for age, sex, Simplified Acute Physiology Score 3 (SAPS 3) and length of stay. ORs on the emergence of P. aeruginosa resistance were also calculated for the various modes of administration. Included were 187 patients [mean age 61 years, 69% male, mean SAPS 3 score (SD): 59 (12.3)]. None of the antibiotics investigated showed the emergence of resistance within 1-3 days. Significant meropenem resistance emerged within 8-15 days [OR 79.1 (14.9-421.0)] after antibiotic exposure unlike other antibiotics (>15 days). No difference was observed between intermittent and extended administration of meropenem and between beta-lactam mono- or combined therapy. Use of meropenem was associated with the emergence of resistance as soon as 8 days after exposure to the antibiotic. |
X Demographics
The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 6 | 19% |
| Spain | 4 | 13% |
| Denmark | 1 | 3% |
| Japan | 1 | 3% |
| Croatia | 1 | 3% |
| Chile | 1 | 3% |
| United States | 1 | 3% |
| Unknown | 16 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 26 | 84% |
| Practitioners (doctors, other healthcare professionals) | 3 | 10% |
| Scientists | 1 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 15% |
| Researcher | 9 | 13% |
| Student > Bachelor | 7 | 10% |
| Student > Postgraduate | 6 | 9% |
| Student > Doctoral Student | 3 | 4% |
| Other | 12 | 18% |
| Unknown | 21 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 9% |
| Immunology and Microbiology | 6 | 9% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Nursing and Health Professions | 3 | 4% |
| Other | 10 | 15% |
| Unknown | 23 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2017.
All research outputs
#1,665,460
of 24,503,376 outputs
Outputs from Annals of Intensive Care
#203
of 1,125 outputs
Outputs of similar age
#32,660
of 319,565 outputs
Outputs of similar age from Annals of Intensive Care
#5
of 29 outputs
Altmetric has tracked 24,503,376 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,125 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.4. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,565 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.