| Title |
Osteomacs and Bone Regeneration
|
|---|---|
| Published in |
Current Osteoporosis Reports, June 2017
|
| DOI | 10.1007/s11914-017-0384-x |
| Pubmed ID | |
| Authors |
Lena Batoon, Susan Marie Millard, Liza Jane Raggatt, Allison Robyn Pettit |
| Abstract |
Mounting evidence supporting the critical contribution of macrophages, in particular osteal macrophages, to bone regeneration is reviewed. We specifically examine the potential role of macrophages in the basic multicellular units coordinating lifelong bone regeneration via remodelling and bone regeneration in response to injury. We review and discuss the distinctions between macrophage and osteoclast contributions to bone homeostasis, particularly the dichotomous role of the colony-stimulating factor 1-colony-stimulating factor 1 receptor axis. The impact of inflammation associated with aging and other hallmarks of aging, including senescence, on macrophage function is addressed in the context of osteoporosis and delayed fracture repair. Resident macrophages versus recruited macrophage contributions to fracture healing are also discussed. We identify some of the remaining knowledge gaps that will need to be closed in order to maximise benefits from therapeutically modulating or mimicking the function of macrophages to improve bone health and regeneration over a lifetime. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 50% |
| Australia | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 101 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 15% |
| Researcher | 12 | 12% |
| Student > Master | 11 | 11% |
| Student > Bachelor | 11 | 11% |
| Student > Doctoral Student | 9 | 9% |
| Other | 14 | 14% |
| Unknown | 29 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 24% |
| Biochemistry, Genetics and Molecular Biology | 19 | 19% |
| Engineering | 6 | 6% |
| Immunology and Microbiology | 5 | 5% |
| Agricultural and Biological Sciences | 2 | 2% |
| Other | 9 | 9% |
| Unknown | 36 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2017.
All research outputs
#15,625,489
of 23,846,647 outputs
Outputs from Current Osteoporosis Reports
#310
of 574 outputs
Outputs of similar age
#191,524
of 318,633 outputs
Outputs of similar age from Current Osteoporosis Reports
#12
of 18 outputs
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So far Altmetric has tracked 574 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.