| Title |
Gut Microbiome and Bone: to Build, Destroy, or Both?
|
|---|---|
| Published in |
Current Osteoporosis Reports, June 2017
|
| DOI | 10.1007/s11914-017-0382-z |
| Pubmed ID | |
| Authors |
Jing Yan, Julia F. Charles |
| Abstract |
The gut microbiota can be considered a hidden organ that plays essential roles in host homeostasis. Exploration of the effects of microbiota on bone has just begun. Complimentary studies using germ-free mice, antibiotic, and probiotic treatments reveal a complicated relationship between microbiota and bone. Here, we review recent reports addressing the effect of gut microbiota on bone health, discuss potential reasons for discrepant findings, and explore potential mechanisms for these effects. Manipulation of microbiota by colonization of germ-free mice, antibiotics, or probiotic supplementation significantly alters bone remodeling, bone development and growth, as well as bone mechanical strength. Different experimental models reveal context-dependent effects of gut microbiota on bone. By examining phenotypic effects, experimental context, and proposed mechanisms, revealed by recent reports, we hope to provide comprehensive and fresh insights into the many facets of microbiota and bone interactions. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 25% |
| Unknown | 6 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 123 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 15% |
| Student > Ph. D. Student | 15 | 12% |
| Student > Bachelor | 11 | 9% |
| Other | 10 | 8% |
| Student > Doctoral Student | 7 | 6% |
| Other | 24 | 20% |
| Unknown | 38 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 18% |
| Agricultural and Biological Sciences | 13 | 11% |
| Biochemistry, Genetics and Molecular Biology | 11 | 9% |
| Immunology and Microbiology | 8 | 7% |
| Nursing and Health Professions | 7 | 6% |
| Other | 18 | 15% |
| Unknown | 44 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2021.
All research outputs
#3,299,504
of 25,874,560 outputs
Outputs from Current Osteoporosis Reports
#70
of 624 outputs
Outputs of similar age
#56,957
of 335,402 outputs
Outputs of similar age from Current Osteoporosis Reports
#5
of 22 outputs
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