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Suppressing the CRISPR/Cas adaptive immune system in bacterial infections

Overview of attention for article published in European Journal of Clinical Microbiology & Infectious Diseases, June 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

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9 X users
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1 Wikipedia page

Citations

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34 Dimensions

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81 Mendeley
Title
Suppressing the CRISPR/Cas adaptive immune system in bacterial infections
Published in
European Journal of Clinical Microbiology & Infectious Diseases, June 2017
DOI 10.1007/s10096-017-3036-2
Pubmed ID
Authors

P. Gholizadeh, M. Aghazadeh, M. Asgharzadeh, H. S. Kafil

Abstract

Clustered regularly interspaced short palindromic repeats (CRISPR) coupled with CRISPR-associated (Cas) proteins (CRISPR/Cas) are the adaptive immune system of eubacteria and archaebacteria. This system provides protection of bacteria against invading foreign DNA, such as transposons, bacteriophages and plasmids. Three-stage processes in this system for immunity against foreign DNAs are defined as adaptation, expression and interference. Recent studies suggested a correlation between the interfering of the CRISPR/Cas locus, acquisition of antibiotic resistance and pathogenicity island. In this review article, we demonstrate and discuss the CRISPR/Cas system's roles in interference with acquisition of antibiotic resistance and pathogenicity island in some eubacteria. Totally, these systems function as the adaptive immune system of bacteria against invading foreign DNA, blocking the acquisition of antibiotic resistance and virulence factor, detecting serotypes, indirect effects of CRISPR self-targeting, associating with physiological functions, associating with infections in humans at the transmission stage, interfering with natural transformation, a tool for genome editing in genome engineering, monitoring foodborne pathogens etc. These results showed that the CRISPR/Cas system might prevent the emergence of virulence both in vitro and in vivo. Moreover, this system was shown to be a strong selective pressure for the acquisition of antibiotic resistance and virulence factor in bacterial pathogens.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 81 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 23%
Student > Bachelor 15 19%
Researcher 9 11%
Student > Ph. D. Student 8 10%
Professor > Associate Professor 3 4%
Other 10 12%
Unknown 17 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 25%
Agricultural and Biological Sciences 17 21%
Immunology and Microbiology 6 7%
Medicine and Dentistry 4 5%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 7 9%
Unknown 24 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2019.
All research outputs
#5,469,998
of 22,979,862 outputs
Outputs from European Journal of Clinical Microbiology & Infectious Diseases
#556
of 2,791 outputs
Outputs of similar age
#86,584
of 317,392 outputs
Outputs of similar age from European Journal of Clinical Microbiology & Infectious Diseases
#7
of 56 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,791 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,392 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.