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Scorpion neurotoxin AaIT-expressing Beauveria bassiana enhances the virulence against Aedes albopictus mosquitoes

Overview of attention for article published in AMB Express, June 2017
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Title
Scorpion neurotoxin AaIT-expressing Beauveria bassiana enhances the virulence against Aedes albopictus mosquitoes
Published in
AMB Express, June 2017
DOI 10.1186/s13568-017-0422-1
Pubmed ID
Authors

Sheng-Qun Deng, Qun-Di Cai, Ming-Zhi Deng, Qiang Huang, Hong-Juan Peng

Abstract

To improve the insecticidal efficacy of this entomopathogen Beauveria bassiana, the fungus was genetically modified to express an insect-specific scorpion neurotoxin AaIT. The virulence of the recombinant B. bassiana strain (Bb-AaIT) against Aedes albopictus adults (which occurs via penetration through the cuticle during spore germination or by conidia ingestion), and the larvae (by conidia ingestion) was measured with bioassays. The median lethal concentration (LC50) of Bb-AaIT against A. albopictus larvae was 313.3-fold lower on day 4 and 11.3-fold lower on day 10 than that of the wild type (WT). Through conidia feeding or body contact, Bb-AaIT killed 50% of adult female mosquitoes at 3.9- or 1.9-fold reduced concentrations on day 4 and at 2.1- or 2.4-fold reduced concentrations on day 10. Compared with the results for the WT, the median lethal time (LT50) of Bb-AaIT was reduced by 28.6% at 1 × 10(7) conidia ml(-1) and 34.3% at 1 × 10(6) conidia ml(-1) in the larvae bioassay by conidia ingestion, while it decreased 32.3% at 1 × 10(7) conidia ml(-1) by conidia ingestion and 24.2% at 1 × 10(8) conidia ml(-1) by penetrating through the cuticle in the adult bioassay. All the differences were significant. Our findings indicated that Bb-AaIT had higher virulence and faster action than the WT in killing the larval and adult mosquitoes, and therefore, it is valuable for development as a commercial mosquito pesticide.

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Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 18%
Student > Bachelor 3 14%
Student > Ph. D. Student 2 9%
Student > Doctoral Student 1 5%
Other 1 5%
Other 4 18%
Unknown 7 32%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 32%
Biochemistry, Genetics and Molecular Biology 4 18%
Arts and Humanities 1 5%
Immunology and Microbiology 1 5%
Medicine and Dentistry 1 5%
Other 0 0%
Unknown 8 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2017.
All research outputs
#20,427,593
of 22,979,862 outputs
Outputs from AMB Express
#972
of 1,239 outputs
Outputs of similar age
#275,810
of 317,132 outputs
Outputs of similar age from AMB Express
#68
of 70 outputs
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