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Bronchial microbiome of severe COPD patients colonised by Pseudomonas aeruginosa

Overview of attention for article published in European Journal of Clinical Microbiology & Infectious Diseases, January 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

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2 tweeters
googleplus
1 Google+ user

Citations

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60 Dimensions

Readers on

mendeley
87 Mendeley
Title
Bronchial microbiome of severe COPD patients colonised by Pseudomonas aeruginosa
Published in
European Journal of Clinical Microbiology & Infectious Diseases, January 2014
DOI 10.1007/s10096-013-2044-0
Pubmed ID
Authors

L. Millares, R. Ferrari, M. Gallego, M. Garcia-Nuñez, V. Pérez-Brocal, M. Espasa, X. Pomares, C. Monton, A. Moya, E. Monsó

Abstract

The bronchial microbiome in severe COPD during stability and exacerbation in patients chronically colonised by Pseudomonas aeruginosa (PA), has not been defined. Our objective was to determine the characteristics of the bronchial microbiome of severe COPD patients colonised and not colonised by P. aeruginosa and its changes during exacerbation. COPD patients with severe disease and frequent exacerbations were categorised according to chronic colonisation by P. aeruginosa. Sputum samples were obtained in stability and exacerbation, cultured, and analysed by 16S rRNA gene amplification and pyrosequencing. Sixteen patients were included, 5 of them showing chronic colonisation by P. aeruginosa. Pseudomonas genus had significantly higher relative abundance in stable colonised patients (p = 0.019), but no significant differences in biodiversity parameters were found between the two groups (Shannon, 3 (2-4) vs 3 (2-3), p = 0.699; Chao1, 124 (77-159) vs 140 (115-163), p = 0.364). In PA-colonised patients bronchial microbiome changed to a microbiome similar to non-PA-colonised patients during exacerbations. An increase in the relative abundance over 20 % during exacerbation was found for Streptococcus, Pseudomonas, Moraxella, Haemophilus, Neisseria, Achromobacter and Corynebacterium genera, which include recognised potentially pathogenic microorganisms, in 13 patients colonised and not colonised by P. aeruginosa with paired samples. These increases were not identified by culture in 5 out of 13 participants (38.5 %). Stable COPD patients with severe disease and PA-colonised showed a similar biodiversity to non-PA-colonised patients, with a higher relative abundance of Pseudomonas genus in bronchial secretions. Exacerbation in severe COPD patients showed the same microbial pattern, independently of previous colonisation by P. aeruginosa.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 2 2%
United Kingdom 1 1%
Korea, Republic of 1 1%
Unknown 83 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 25%
Student > Ph. D. Student 19 22%
Student > Master 9 10%
Unspecified 8 9%
Other 8 9%
Other 21 24%
Readers by discipline Count As %
Medicine and Dentistry 35 40%
Agricultural and Biological Sciences 17 20%
Unspecified 15 17%
Immunology and Microbiology 9 10%
Biochemistry, Genetics and Molecular Biology 6 7%
Other 5 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2014.
All research outputs
#6,328,200
of 12,226,394 outputs
Outputs from European Journal of Clinical Microbiology & Infectious Diseases
#987
of 1,790 outputs
Outputs of similar age
#81,480
of 224,125 outputs
Outputs of similar age from European Journal of Clinical Microbiology & Infectious Diseases
#13
of 44 outputs
Altmetric has tracked 12,226,394 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,790 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,125 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.