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An observational study of 110 elderly lithium-treated patients followed up for 6 years with particular reference to renal function

Overview of attention for article published in International Journal of Bipolar Disorders, June 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

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4 tweeters
facebook
1 Facebook page

Citations

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17 Dimensions

Readers on

mendeley
33 Mendeley
Title
An observational study of 110 elderly lithium-treated patients followed up for 6 years with particular reference to renal function
Published in
International Journal of Bipolar Disorders, June 2017
DOI 10.1186/s40345-017-0089-1
Pubmed ID
Authors

Alberto Bocchetta, Francesca Cabras, Martina Pinna, Antonio Poddighe, Claudia Sardu, Raffaella Ardau, Caterina Chillotti, Maria Del Zompo

Abstract

Recent observational studies have focused on lithium treatment in the elderly, with particular reference to safety in terms of thyroid and renal functions. The purpose of this study was to compare the clinical characteristics of patients starting lithium treatment before (N = 79) or after (N = 31) the age of 65 years. Patients were followed up for 6 years with focus on renal function and prescription of levothyroxine and methimazole. At baseline, median lithium serum concentration was 0.55 mmol/l. The estimated glomerular filtration rate was lower than 60 ml/min/1.73 m(2) in 43 (39%) patients. In a multiple regression analysis controlling for age and gender, we found a significant effect of duration of lithium treatment on estimated glomerular filtration rate (-0.85 ml/min/1.73 m(2) per year of prior exposure). The annual decline during follow-up was 2.3 ml/min/1.73 m(2). Two patients were prescribed levothyroxine, and two were prescribed methimazole for the first time during follow-up. Median lithium serum concentration in this cohort of elderly patients with mainly bipolar disorders was lower than the therapeutic range indicated for younger adults. The decline in glomerular filtration rate may be accelerated by long-term lithium use. Thyroid and renal functions continue to require close monitoring throughout the course of lithium treatment. Trial registration NP/2013/3836. Registered 24 June 2013.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 15%
Student > Bachelor 5 15%
Student > Doctoral Student 4 12%
Student > Postgraduate 3 9%
Student > Master 3 9%
Other 7 21%
Unknown 6 18%
Readers by discipline Count As %
Medicine and Dentistry 15 45%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Nursing and Health Professions 2 6%
Unspecified 2 6%
Computer Science 2 6%
Other 4 12%
Unknown 6 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2017.
All research outputs
#9,873,525
of 18,166,797 outputs
Outputs from International Journal of Bipolar Disorders
#136
of 239 outputs
Outputs of similar age
#120,698
of 280,411 outputs
Outputs of similar age from International Journal of Bipolar Disorders
#2
of 6 outputs
Altmetric has tracked 18,166,797 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 239 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,411 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.