| Title |
Direct comparison of the acute subjective, emotional, autonomic, and endocrine effects of MDMA, methylphenidate, and modafinil in healthy subjects
|
|---|---|
| Published in |
Psychopharmacology, May 2017
|
| DOI | 10.1007/s00213-017-4650-5 |
| Pubmed ID | |
| Authors |
Patrick C. Dolder, Felix Müller, Yasmin Schmid, Stefan J. Borgwardt, Matthias E. Liechti |
| Abstract |
3,4-Methylenedioxymethamphetamine (MDMA) is used recreationally and investigated as an adjunct to psychotherapy. Methylphenidate and modafinil are psychostimulants that are used to treat attention-deficit/hyperactivity disorder and narcolepsy, respectively, but they are also misused as cognitive enhancers. Little is known about differences in the acute effects of equally cardiostimulant doses of these stimulant-type substances compared directly within the same subjects. We investigated the acute autonomic, subjective, endocrine, and emotional effects of single doses of MDMA (125 mg), methylphenidate (60 mg), modafinil (600 mg), and placebo in a double-blind, cross-over study in 24 healthy participants. Acute drug effects were tested using psychometric scales, the Facial Emotion Recognition Task (FERT), and the Sexual Arousal and Desire Inventory (SADI). All active drugs produced comparable hemodynamic and adverse effects. MDMA produced greater increases in pupil dilation, subjective good drug effects, drug liking, happiness, trust, well-being, and alterations in consciousness than methylphenidate or modafinil. Only MDMA reduced subjective anxiety and impaired fear recognition and led to misclassifications of emotions as happy on the FERT. On the SADI, only MDMA produced sexual arousal-like effects. Only MDMA produced marked increases in cortisol, prolactin, and oxytocin. In contrast to MDMA, methylphenidate increased subjective anxiety, and methylphenidate and modafinil increased misclassifications of emotions as angry on the FERT. Modafinil had no significant subjective drug effects but significant sympathomimetic and adverse effects. MDMA induced subjective, emotional, sexual, and endocrine effects that were clearly distinct from those of methylphenidate and modafinil at the doses used. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 17% |
| San Marino | 1 | 17% |
| United Kingdom | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 229 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 229 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 40 | 17% |
| Student > Master | 39 | 17% |
| Student > Ph. D. Student | 22 | 10% |
| Researcher | 20 | 9% |
| Student > Doctoral Student | 7 | 3% |
| Other | 29 | 13% |
| Unknown | 72 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 19% |
| Psychology | 32 | 14% |
| Neuroscience | 21 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 7% |
| Nursing and Health Professions | 6 | 3% |
| Other | 27 | 12% |
| Unknown | 83 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2024.
All research outputs
#1,494,831
of 25,944,331 outputs
Outputs from Psychopharmacology
#356
of 5,380 outputs
Outputs of similar age
#28,158
of 331,416 outputs
Outputs of similar age from Psychopharmacology
#3
of 51 outputs
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So far Altmetric has tracked 5,380 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done particularly well, scoring higher than 93% of its peers.
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