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Natural Genetic Variation Underlying Differences in Peromyscus Repetitive and Social/Aggressive Behaviors

Overview of attention for article published in Behavior Genetics, January 2014
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Title
Natural Genetic Variation Underlying Differences in Peromyscus Repetitive and Social/Aggressive Behaviors
Published in
Behavior Genetics, January 2014
DOI 10.1007/s10519-013-9640-8
Pubmed ID
Authors

Kimberly R. Shorter, Amy Owen, Vanessa Anderson, April C. Hall-South, Samantha Hayford, Patricia Cakora, Janet P. Crossland, Velina R. M. Georgi, Amy Perkins, Sandra J. Kelly, Michael R. Felder, Paul B. Vrana

Abstract

Peromyscus maniculatus (BW) and P. polionotus (PO) are interfertile North American species that differ in many characteristics. For example, PO exhibit monogamy and BW animals are susceptible to repetitive behaviors and thus a model for neurobehavioral disorders such as Autism. We analyzed these two stocks as well as their hybrids, a BW Y(PO) consomic line (previously shown to alter glucose homeostasis) and a natural P. maniculatus agouti variant (A(Nb) = wide band agouti). We show that PO animals engage in far less repetitive behavior than BW animals, that this trait is dominant, and that trait distribution in both species is bi-modal. The A(Nb) allele also reduces such behaviors, particularly in females. PO, F1, and A(Nb) animals all dig significantly more than BW. Increased self-grooming is also a PO dominant trait, and there is a bimodal trait distribution in all groups except BW. The inter-stock differences in self-grooming are greater between males, and the consomic data suggest the Y chromosome plays a role. The monogamous PO animals engage in more social behavior than BW; hybrid animals exhibit intermediate levels. Surprisingly, A(Nb) animals are also more social than BW animals, although A(Nb) interactions led to aggressive interactions at higher levels than any other group. PO animals exhibited the lowest incidence of aggressive behaviors, while the hybrids exhibited BW levels. Thus this group exhibits natural, genetically tractable variation in several biomedically relevant traits.

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Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Professor 11 17%
Student > Ph. D. Student 11 17%
Student > Bachelor 10 15%
Student > Master 10 15%
Researcher 7 11%
Other 7 11%
Unknown 9 14%
Readers by discipline Count As %
Psychology 22 34%
Agricultural and Biological Sciences 15 23%
Biochemistry, Genetics and Molecular Biology 5 8%
Medicine and Dentistry 3 5%
Unspecified 2 3%
Other 6 9%
Unknown 12 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2014.
All research outputs
#18,360,179
of 22,739,983 outputs
Outputs from Behavior Genetics
#726
of 907 outputs
Outputs of similar age
#228,918
of 304,956 outputs
Outputs of similar age from Behavior Genetics
#9
of 11 outputs
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