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Caffeine as a psychomotor stimulant: mechanism of action

Overview of attention for article published in Cellular & Molecular Life Sciences, April 2004
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
1 news outlet
twitter
1 tweeter
facebook
1 Facebook page
wikipedia
1 Wikipedia page
video
2 video uploaders

Citations

dimensions_citation
285 Dimensions

Readers on

mendeley
336 Mendeley
citeulike
1 CiteULike
Title
Caffeine as a psychomotor stimulant: mechanism of action
Published in
Cellular & Molecular Life Sciences, April 2004
DOI 10.1007/s00018-003-3269-3
Pubmed ID
Authors

G. Fisone, A. Borgkvist, A. Usiello

Abstract

The popularity of caffeine as a psychoactive drug is due to its stimulant properties, which depend on its ability to reduce adenosine transmission in the brain. Adenosine A(1) and A(2A) receptors are expressed in the basal ganglia, a group of structures involved in various aspects of motor control. Caffeine acts as an antagonist to both types of receptors. Increasing evidence indicates that the psychomotor stimulant effect of caffeine is generated by affecting a particular group of projection neurons located in the striatum, the main receiving area of the basal ganglia. These cells express high levels of adenosine A(2A) receptors, which are involved in various intracellular processes, including the expression of immediate early genes and regulation of the dopamine- and cyclic AMP-regulated 32-kDa phosphoprotein DARPP-32. The present review focuses on the effects of caffeine on striatal signal transduction and on their involvement in caffeine-mediated motor stimulation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 336 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 <1%
United States 2 <1%
France 2 <1%
United Kingdom 2 <1%
Mexico 1 <1%
Malaysia 1 <1%
Australia 1 <1%
Poland 1 <1%
Portugal 1 <1%
Other 2 <1%
Unknown 320 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 140 42%
Student > Master 47 14%
Student > Ph. D. Student 37 11%
Unspecified 31 9%
Researcher 26 8%
Other 55 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 83 25%
Medicine and Dentistry 48 14%
Unspecified 36 11%
Chemistry 28 8%
Biochemistry, Genetics and Molecular Biology 27 8%
Other 114 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2018.
All research outputs
#1,023,432
of 13,165,892 outputs
Outputs from Cellular & Molecular Life Sciences
#71
of 2,601 outputs
Outputs of similar age
#21,146
of 250,721 outputs
Outputs of similar age from Cellular & Molecular Life Sciences
#3
of 33 outputs
Altmetric has tracked 13,165,892 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,601 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,721 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.