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Hypoxia and cancer

Overview of attention for article published in Journal of Molecular Medicine, November 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

patent
2 patents
facebook
1 Facebook page

Citations

dimensions_citation
383 Dimensions

Readers on

mendeley
412 Mendeley
Title
Hypoxia and cancer
Published in
Journal of Molecular Medicine, November 2007
DOI 10.1007/s00109-007-0281-3
Pubmed ID
Authors

M. Christiane Brahimi-Horn, Johanna Chiche, Jacques Pouysségur

Abstract

A major feature of solid tumours is hypoxia, decreased availability of oxygen, which increases patient treatment resistance and favours tumour progression. How hypoxic conditions are generated in tumour tissues and how cells respond to hypoxia are essential questions in understanding tumour progression and metastasis. Massive tumour-cell proliferation distances cells from the vasculature, leading to a deficiency in the local environment of blood carrying oxygen and nutrients. Such hypoxic conditions induce a molecular response, in both normal and neoplastic cells, that drives the activation of a key transcription factor; the hypoxia-inducible factor. This transcription factor regulates a large panel of genes that are exploited by tumour cells for survival, resistance to treatment and escape from a nutrient-deprived environment. Although now recognized as a major contributor to cancer progression and to treatment failure, the precise role of hypoxia signalling in cancer and in prognosis still needs to be further defined. It is hoped that a better understanding of the mechanisms implicated will lead to alternative and more efficient therapeutic approaches.

Mendeley readers

The data shown below were compiled from readership statistics for 412 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 11 3%
India 2 <1%
Belgium 2 <1%
United Kingdom 2 <1%
Brazil 1 <1%
France 1 <1%
Ireland 1 <1%
Japan 1 <1%
Germany 1 <1%
Other 3 <1%
Unknown 387 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 103 25%
Student > Master 78 19%
Researcher 72 17%
Student > Bachelor 53 13%
Student > Doctoral Student 23 6%
Other 83 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 147 36%
Biochemistry, Genetics and Molecular Biology 75 18%
Medicine and Dentistry 64 16%
Chemistry 39 9%
Unspecified 29 7%
Other 58 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2014.
All research outputs
#1,795,233
of 11,256,737 outputs
Outputs from Journal of Molecular Medicine
#92
of 1,014 outputs
Outputs of similar age
#32,560
of 195,321 outputs
Outputs of similar age from Journal of Molecular Medicine
#3
of 7 outputs
Altmetric has tracked 11,256,737 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,014 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,321 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.