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Polymorphisms in Folate-Related Enzyme Genes in Idiopathic Infertile Brazilian Men

Overview of attention for article published in Reproductive Sciences, July 2011
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Title
Polymorphisms in Folate-Related Enzyme Genes in Idiopathic Infertile Brazilian Men
Published in
Reproductive Sciences, July 2011
DOI 10.1177/1933719111411729
Pubmed ID
Authors

Marcello M. Gava, Erika A. Kayaki, Bianca Bianco, Juliana S. Teles, Denise M. Christofolini, Antonio C. L. Pompeo, Sidney Glina, Caio P. Barbosa

Abstract

The aim of the study was to analyze the distribution of the methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), and methionine synthase (MTR) polymorphisms in idiopathic infertile Brazilian men and fertile men. Case-control study comprising 133 idiopathic infertile Brazilian men with nonobstructive azoospermia ([NOA] n = 55) or severe oligozoospermia ([SO] n = 78) and 173 fertile men as controls. MTHFR C677T, A1298C, and G1793A; MTRR A66G; and MTR A2756G polymorphisms were studied by quantitative polymerase chain reaction (qPCR). The results were analyzed statistically and a P value <.05 was considered significant. Single-marker analysis revealed a significant association among MTHFR C677T polymorphism and both NOA group (P = .018) and SO group (P < .001). Considering the MTHFR A1298C, MTHFR G1793A, and MTRR A66G polymorphisms, no difference was found between NOA group and SO group. Regarding the MTR A2756G polymorphism, a significant difference was found between NOA and controls, P = .017. However, statistical analysis revealed no association between SO group and controls. Combined genotypes of 3 MTHFR polymorphisms did not identify a haplotype associated with idiopathic infertility. The combinatory analysis of the 3 polymorphisms MTHFR, MTRR, and MTR did not show difference between cases and controls. The findings suggest the MTHFR C677T and MTR A2756G polymorphisms could be an important genetic factor predisposing to idiopathic infertility in Brazilian men.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 18%
Professor 3 18%
Student > Postgraduate 3 18%
Student > Ph. D. Student 2 12%
Researcher 2 12%
Other 2 12%
Unknown 2 12%
Readers by discipline Count As %
Medicine and Dentistry 8 47%
Pharmacology, Toxicology and Pharmaceutical Science 3 18%
Agricultural and Biological Sciences 2 12%
Biochemistry, Genetics and Molecular Biology 1 6%
Unknown 3 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2011.
All research outputs
#10,037,246
of 12,544,848 outputs
Outputs from Reproductive Sciences
#315
of 604 outputs
Outputs of similar age
#66,157
of 83,687 outputs
Outputs of similar age from Reproductive Sciences
#5
of 5 outputs
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