Title |
Significant associations between X-ray repair cross-complementing group 3 genetic polymorphisms and thyroid cancer risk
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Published in |
Tumor Biology, November 2013
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DOI | 10.1007/s13277-013-1266-1 |
Pubmed ID | |
Authors |
Xiao-Long Yu, Hu Liu, Bin Wang, Zheng-Ju Fu, Ying Yuan, Sheng-Li Yan, Wen-Juan Zhao, Yan-Gang Wang, Jianming Cai |
Abstract |
Polymorphisms in X-ray cross-complementing group 3 (XRCC3) are proposed to be associated with cancer susceptibility, but previous studies on the associations between XRCC3 polymorphisms and thyroid cancer are controversial. We performed a systemic review and meta-analysis to investigate the associations of XRCC3 polymorphisms with thyroid cancer risk. We used odds ratio (OR) with 95 % confidence interval (95%CI) to assess the associations. For XRCC3 C241T polymorphism, meta-analysis of total eligible studies showed that there was no association between XRCC3 C241T polymorphism and thyroid cancer risk, but subgroup analysis in Caucasians showed that there was a significant association between XRCC3 C241T polymorphism and thyroid cancer risk (T versus C: OR = 1.30, 95%CI 1.05-1.62, P = 0.01; TT versus CC: OR = 1.74, 95%CI 1.13-2.70, P = 0.01; TT versus |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 2 | 18% |
Student > Master | 2 | 18% |
Professor | 1 | 9% |
Lecturer | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Other | 0 | 0% |
Unknown | 4 | 36% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 3 | 27% |
Engineering | 2 | 18% |
Agricultural and Biological Sciences | 1 | 9% |
Biochemistry, Genetics and Molecular Biology | 1 | 9% |
Unknown | 4 | 36% |