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Inflammation and Alzheimer’s disease

Overview of attention for article published in Archives of Pharmacal Research, October 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
235 Dimensions

Readers on

mendeley
1348 Mendeley
Title
Inflammation and Alzheimer’s disease
Published in
Archives of Pharmacal Research, October 2010
DOI 10.1007/s12272-010-1006-7
Pubmed ID
Authors

Young-Jung Lee, Sang Bae Han, Sang-Yoon Nam, Ki-Wan Oh, Jin Tae Hong

Abstract

Alzheimer's disease (AD) is the most common form of dementia. It is characterized by extracellular deposition of a specific protein, beta-amyloid peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals. Although the pathophysiologic mechanism is not fully established, inflammation appears to be involved. Neuroinflammation has been known to play a critical role in the pathogenesis of chronic neurodegenerative disease in general, and in AD in particular. Numerous studies show the presence of a number of markers of inflammation in the AD brain: elevated inflammatory cytokines and chemokines, and accumulation of activated microglia in the damaged regions. Epidemiological studies have shown that long-term use of non-steroidal anti-inflammatory drugs suppresses the progression of AD and delays its onset, suggesting that there is a close correlation between neuroinflammation and AD pathogenesis. The aim of this review is (1) to assess the association between neuroinflammation and AD through discussion of a variety of experimental and clinical studies on AD and (2) to review treatment strategies designed to treat or prevent AD.

Mendeley readers

The data shown below were compiled from readership statistics for 1,348 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 26 2%
United Kingdom 12 <1%
Spain 6 <1%
Germany 3 <1%
France 3 <1%
China 2 <1%
Netherlands 2 <1%
Canada 2 <1%
Colombia 2 <1%
Other 19 1%
Unknown 1271 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 302 22%
Student > Master 248 18%
Student > Bachelor 245 18%
Researcher 189 14%
Unspecified 90 7%
Other 274 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 430 32%
Medicine and Dentistry 235 17%
Neuroscience 179 13%
Unspecified 145 11%
Biochemistry, Genetics and Molecular Biology 133 10%
Other 226 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2011.
All research outputs
#2,747,341
of 12,646,662 outputs
Outputs from Archives of Pharmacal Research
#175
of 913 outputs
Outputs of similar age
#19,637
of 83,460 outputs
Outputs of similar age from Archives of Pharmacal Research
#3
of 7 outputs
Altmetric has tracked 12,646,662 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 913 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 83,460 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.