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Nephrotoxicity of methadone: a systematic review

Overview of attention for article published in SpringerPlus, December 2016
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2 tweeters
1 Facebook page


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Readers on

44 Mendeley
Nephrotoxicity of methadone: a systematic review
Published in
SpringerPlus, December 2016
DOI 10.1186/s40064-016-3757-1
Pubmed ID

Samira Alinejad, Kazem Ghaemi, Mohammad Abdollahi, Omid Mehrpour


Methadone is commonly administered for chronic pain relief and treatment of opioid dependence. Concurrent with its increased consumption, toxicities and fatalities have increased. One of the adverse effects of opioid analgesics, including methadone, is that of nephrotoxicity. Opioids can have an effect on renal function through several different mechanisms. We searched common bibliographical databases for the terms methadone, toxicity, poisoning, kidney, renal, and nephrotoxicity and summarize our findings in this review. Methadone can have both direct and indirect effects on the kidney. These effects include rhabdomyolysis (leading to acute kidney injury), volumetric changes, renal lipidosis and amyloidosis, kidney growth during pregnancy, and kidney transplant rejection. Improved understanding of the effects of methadone on kidney function can promote safer and more confident use of the drug.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 16%
Student > Ph. D. Student 6 14%
Student > Doctoral Student 6 14%
Student > Postgraduate 4 9%
Researcher 4 9%
Other 9 20%
Unknown 8 18%
Readers by discipline Count As %
Medicine and Dentistry 17 39%
Neuroscience 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Nursing and Health Professions 2 5%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 2 5%
Unknown 16 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2019.
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