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Corpus callosum involvement: a useful clue for differentiating Fabry Disease from Multiple Sclerosis

Overview of attention for article published in Neuroradiology, April 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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44 Mendeley
Title
Corpus callosum involvement: a useful clue for differentiating Fabry Disease from Multiple Sclerosis
Published in
Neuroradiology, April 2017
DOI 10.1007/s00234-017-1829-8
Pubmed ID
Authors

Sirio Cocozza, Gaia Olivo, Eleonora Riccio, Camilla Russo, Giuseppe Pontillo, Lorenzo Ugga, Silvia Migliaccio, Dario de Rosa, Sandro Feriozzi, Massimiliano Veroux, Yuri Battaglia, Daniela Concolino, Federico Pieruzzi, Antonino Tuttolomondo, Aurelio Caronia, Cinzia Valeria Russo, Roberta Lanzillo, Vincenzo Brescia Morra, Massimo Imbriaco, Arturo Brunetti, Enrico Tedeschi, Antonio Pisani

Abstract

Multiple sclerosis (MS) has been proposed as a possible differential diagnosis for Fabry disease (FD). The aim of this work was to evaluate the involvement of corpus callosum (CC) on MR images and its possible role as a radiological sign to differentiate between FD and MS. In this multicentric study, we retrospectively evaluated the presence of white matter lesions (WMLs) on the FLAIR images of 104 patients with FD and 117 patients with MS. The incidence of CC-WML was assessed in the two groups and also in a subgroup of 37 FD patients showing neurological symptoms. WMLs were detected in 50 of 104 FD patients (48.1%) and in all MS patients. However, a lesion in the CC was detected in only 3 FD patients (2.9%) and in 106 MS patients (90.6%). In the FD subgroup with neurological symptoms, WMLs were present in 26 of 37 patients (70.3%), with two subjects (5.4%) showing a definite callosal lesion. FD patients have a very low incidence of CC involvement on conventional MR images compared to MS, independently from the clinical presentation and the overall degree of WM involvement. Evaluating the presence of CC lesions on brain MR scans can be used as a radiological sign for a differential diagnosis between MS and FD, rapidly addressing the physician toward a correct diagnosis and subsequent treatment options.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 6 14%
Other 5 11%
Researcher 5 11%
Student > Bachelor 4 9%
Student > Ph. D. Student 4 9%
Other 6 14%
Unknown 14 32%
Readers by discipline Count As %
Medicine and Dentistry 14 32%
Neuroscience 7 16%
Nursing and Health Professions 2 5%
Economics, Econometrics and Finance 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 1 2%
Unknown 18 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2017.
All research outputs
#12,972,426
of 22,962,258 outputs
Outputs from Neuroradiology
#555
of 1,398 outputs
Outputs of similar age
#148,412
of 309,589 outputs
Outputs of similar age from Neuroradiology
#13
of 35 outputs
Altmetric has tracked 22,962,258 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,398 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,589 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.