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Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas

Overview of attention for article published in Journal of Neuro-Oncology, October 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 2,028)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

policy
1 policy source
twitter
30 tweeters
patent
1 patent
facebook
300 Facebook pages
googleplus
1 Google+ user
video
1 video uploader

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
76 Mendeley
Title
Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
Published in
Journal of Neuro-Oncology, October 2013
DOI 10.1007/s11060-013-1277-1
Pubmed ID
Authors

Francisco Carlos Machado Rocha, Jair Guilherme dos Santos Júnior, Sergio Carlos Stefano, Dartiu Xavier da Silveira

Abstract

To evaluate, through a systematic review of the literature, the antitumoral effects of cannabinoids on gliomas. Research included the following electronic databases: PUBMED, EMBASE, LILACS and The Cochrane Collaboration Controlled Trials Register. All published studies involving the antitumoral effects (cellular and molecular mechanisms) of cannabinoids were considered for this review. The bibliography search strategy included all publications of each of these databases until December 31, 2012. From 2,260 initially identified articles, 35 fulfilled the inclusion criteria for this review. All the studies included in this systematic review were experimental (in vivo and/or in vitro), except for one pilot clinical trial phase I/II involving humans. In all experimental studies included, cannabinoids exerted antitumoral activity in vitro and/or antitumoral evidence in vivo in several models of tumor cells and tumors. The antitumor activity included: antiproliferative effects (cell cycle arrest), decreased viability and cell death by toxicity, apoptosis, necrosis, autophagy, as well as antiangiogenic and antimigratory effects. Antitumoral evidence included: reduction in tumor size, antiangiogenic, and antimetastatic effects. Additionally, most of the studies described that the canabinnoids exercised selective antitumoral action in several distinct tumor models. Thereby, normal cells used as controls were not affected. The safety factor in the cannabinoids' administration has also been demonstrated in vivo. The various cannabinoids tested in multiple tumor models showed antitumoral effects both in vitro and in vivo. These findings indicate that cannabinoids are promising compounds for the treatment of gliomas.

Twitter Demographics

The data shown below were collected from the profiles of 30 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Switzerland 1 1%
Unknown 73 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 26%
Unspecified 13 17%
Student > Bachelor 7 9%
Student > Ph. D. Student 7 9%
Student > Master 7 9%
Other 22 29%
Readers by discipline Count As %
Medicine and Dentistry 25 33%
Unspecified 16 21%
Agricultural and Biological Sciences 9 12%
Neuroscience 7 9%
Biochemistry, Genetics and Molecular Biology 5 7%
Other 14 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 103. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2019.
All research outputs
#155,308
of 13,534,362 outputs
Outputs from Journal of Neuro-Oncology
#3
of 2,028 outputs
Outputs of similar age
#2,245
of 182,499 outputs
Outputs of similar age from Journal of Neuro-Oncology
#1
of 26 outputs
Altmetric has tracked 13,534,362 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,028 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 182,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.