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Combined small cell lung carcinoma and giant cell carcinoma: a case report

Overview of attention for article published in Surgical Case Reports, March 2017
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About this Attention Score

  • Among the highest-scoring outputs from this source (#18 of 488)
  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

twitter
1 tweeter
wikipedia
1 Wikipedia page

Citations

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6 Dimensions

Readers on

mendeley
13 Mendeley
Title
Combined small cell lung carcinoma and giant cell carcinoma: a case report
Published in
Surgical Case Reports, March 2017
DOI 10.1186/s40792-017-0328-9
Pubmed ID
Authors

Tomohito Saito, Koji Tsuta, Kento J. Fukumoto, Hiroshi Matsui, Toshifumi Konobu, Yoshitaro Torii, Takashi Yokoi, Takayasu Kurata, Hiroaki Kurokawa, Yoshiko Uemura, Yukihito Saito, Tomohiro Murakawa

Abstract

Combined small cell lung carcinoma (SCLC) is defined as SCLC combined with elements of non-small cell lung carcinoma (NSCLC), accounting for approximately 30% of cases of SCLC. However, combined SCLC and giant cell carcinoma (GC) is very rare. A 50-year-old woman with a 45 pack-year smoking history was referred to our hospital for further investigation of an abnormal left hilar shadow. Chest computed tomography (CT) revealed a 28-mm solid pulmonary nodule in the left lower lobe and an enlarged left hilar lymph node adjacent to the left main pulmonary artery. CT-guided biopsy of the pulmonary nodule led to the diagnosis of high-grade neuroendocrine carcinoma. The preoperative clinical stage was defined as cT1bN1M0. Thus, the patient underwent left lower lobectomy with ND2a-2 lymph node dissection via thoracotomy. Pathological investigation revealed a 22-mm tumor and dense sheet-like growth of small tumor cells with scant cytoplasm and finely granular nuclear chromatin. Moreover, there was a sheet-like growth of bizarre, highly pleomorphic mono- or occasionally multinucleated giant cells, accounting for approximately 40% of the tumor. Both the small and giant cell components were thyroid transcription factor-1-positive and p40-negative and exhibited neuroendocrine differentiation, as indicated by positivity for synaptophysin and CD56 and negativity for chromogranin A. While the small cell component was E-cadherin-positive and vimentin-negative, the giant cell component was E-cadherin-negative and vimentin-positive, indicating an epithelial-to-mesenchymal transition. Only the small cell component was found within the mediastinal and hilar lymph nodes. The final pathological diagnosis was combined SCLC and GC, pT1bN2M0, and pStage IIIA. The patient received adjuvant chemotherapy with 4 cycles of cisplatin and irinotecan. No sign of recurrence has been noted for 1 year after the surgery. This is the first detailed report of a unique case with combined SCLC and GC. The coexistence of SCLC and GC in the presented case might indicate several possibilities: (1) GC may arise from SCLC via epithelial-to-mesenchymal transition, (2) SCLC may arise from GC through phenotypic conversion, and (3) SCLC and GC may have derived from a common neuroendocrine origin. Further investigation is necessary to reveal the underlying pathological process.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 15%
Student > Postgraduate 2 15%
Student > Bachelor 2 15%
Other 1 8%
Researcher 1 8%
Other 1 8%
Unknown 4 31%
Readers by discipline Count As %
Medicine and Dentistry 4 31%
Nursing and Health Professions 2 15%
Immunology and Microbiology 1 8%
Physics and Astronomy 1 8%
Engineering 1 8%
Other 0 0%
Unknown 4 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2022.
All research outputs
#7,224,902
of 22,835,198 outputs
Outputs from Surgical Case Reports
#18
of 488 outputs
Outputs of similar age
#116,262
of 308,887 outputs
Outputs of similar age from Surgical Case Reports
#2
of 9 outputs
Altmetric has tracked 22,835,198 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 488 research outputs from this source. They receive a mean Attention Score of 0.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 308,887 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.