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Microglia actions in Alzheimer’s disease

Overview of attention for article published in Acta Neuropathologica, September 2013
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Mentioned by

twitter
2 tweeters

Citations

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157 Dimensions

Readers on

mendeley
240 Mendeley
Title
Microglia actions in Alzheimer’s disease
Published in
Acta Neuropathologica, September 2013
DOI 10.1007/s00401-013-1182-x
Pubmed ID
Authors

Stefan Prokop, Kelly R. Miller, Frank L. Heppner

Abstract

The identification of microglia-associated, neurological disease-causing mutations in patients, combined with studies in mouse models has highlighted microglia, the brain's intrinsic myeloid cells, as key modulators of pathogenesis and disease progression in neurodegenerative diseases. In Alzheimer's disease (AD) in particular, the activation and accumulation of microglial cells around β-Amyloid (Aβ) plaques has long been described and is believed to result in chronic neuroinflammation-a term that, despite being commonly used, lacks a precise definition. This seemingly directed response of microglia to amyloid deposits conflicts with the fact that the increasing buildup of Aβ plaques is not inhibited by these cells during disease progression. While recent evidence suggests that microglia lose their intrinsic beneficial function during the course of AD and may even acquire a "toxic" phenotype over time, Aβ may also simply not be an appropriate trigger to induce phagocytosis and degradation by microglia in vivo. As recent experimental evidence has indicated the importance of the microglia in AD pathogenesis, future efforts aimed at tackling this disease via utilization or modulation of microglia or factors therefrom appear to be an exciting and challenging research front.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 240 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 2 <1%
United States 1 <1%
China 1 <1%
Poland 1 <1%
Korea, Republic of 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
Unknown 232 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 61 25%
Student > Master 48 20%
Researcher 38 16%
Student > Bachelor 36 15%
Student > Doctoral Student 15 6%
Other 42 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 74 31%
Neuroscience 49 20%
Biochemistry, Genetics and Molecular Biology 35 15%
Medicine and Dentistry 33 14%
Unspecified 23 10%
Other 26 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2014.
All research outputs
#8,064,463
of 12,855,952 outputs
Outputs from Acta Neuropathologica
#1,366
of 1,612 outputs
Outputs of similar age
#86,020
of 162,978 outputs
Outputs of similar age from Acta Neuropathologica
#14
of 25 outputs
Altmetric has tracked 12,855,952 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,612 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 162,978 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.