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Evaluation of Physical and Chemical Changes in Pharmaceuticals Flown on Space Missions

Overview of attention for article published in The AAPS Journal, April 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#13 of 814)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
7 tweeters
facebook
1 Facebook page
reddit
1 Redditor

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
48 Mendeley
Title
Evaluation of Physical and Chemical Changes in Pharmaceuticals Flown on Space Missions
Published in
The AAPS Journal, April 2011
DOI 10.1208/s12248-011-9270-0
Pubmed ID
Authors

Brian Du, Vernie R. Daniels, Zalman Vaksman, Jason L. Boyd, Camille Crady, Lakshmi Putcha

Abstract

Efficacy and safety of medications used for the treatment of astronauts in space may be compromised by altered stability in space. We compared physical and chemical changes with time in 35 formulations contained in identical pharmaceutical kits stowed on the International Space Station (ISS) and on Earth. Active pharmaceutical content (API) was determined by ultra- and high-performance liquid chromatography after returning to Earth. After stowage for 28 months in space, six medications aboard the ISS and two of matching ground controls exhibited changes in physical variables; nine medications from the ISS and 17 from the ground met the United States Pharmacopeia (USP) acceptance criteria for API content after 28 months of storage. A higher percentage of medications from each flight kit had lower API content than the respective ground controls. The number of medications failing API requirement increased as a function of time in space, independent of expiration date. The rate of degradation was faster in space than on the ground for many of the medications, and most solid dosage forms met USP standard for dissolution after storage in space. Cumulative radiation dose was higher and increased with time in space, whereas temperature and humidity remained similar to those on the ground. Exposure to the chronic low dose of ionizing radiation aboard the spacecraft as well as repackaging of solid dosage forms in flight-specific dispensers may adversely affect stability of pharmaceuticals. Characterization of degradation profiles of unstable formulations and identification of chemical attributes of stability in space analog environments on Earth will facilitate development of space-hardy medications.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
Portugal 1 2%
United Kingdom 1 2%
India 1 2%
Unknown 43 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 29%
Student > Bachelor 11 23%
Researcher 5 10%
Student > Doctoral Student 4 8%
Other 4 8%
Other 10 21%
Readers by discipline Count As %
Chemistry 9 19%
Medicine and Dentistry 6 13%
Engineering 6 13%
Physics and Astronomy 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 4 8%
Other 19 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2019.
All research outputs
#469,545
of 13,333,056 outputs
Outputs from The AAPS Journal
#13
of 814 outputs
Outputs of similar age
#455,303
of 12,685,591 outputs
Outputs of similar age from The AAPS Journal
#13
of 814 outputs
Altmetric has tracked 13,333,056 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 814 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 12,685,591 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 814 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.