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Fibronectin in tissue regeneration: timely disassembly of the scaffold is necessary to complete the build

Overview of attention for article published in Cellular & Molecular Life Sciences, June 2013
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Mentioned by

twitter
3 tweeters

Citations

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41 Dimensions

Readers on

mendeley
84 Mendeley
Title
Fibronectin in tissue regeneration: timely disassembly of the scaffold is necessary to complete the build
Published in
Cellular & Molecular Life Sciences, June 2013
DOI 10.1007/s00018-013-1350-0
Pubmed ID
Authors

Josephine M. J. Stoffels, Chao Zhao, Wia Baron

Abstract

Tissue injury initiates extracellular matrix molecule expression, including fibronectin production by local cells and fibronectin leakage from plasma. To benefit tissue regeneration, fibronectin promotes opsonization of tissue debris, migration, proliferation, and contraction of cells involved in the healing process, as well as angiogenesis. When regeneration proceeds, the fibronectin matrix is fully degraded. However, in a diseased environment, fibronectin clearance is often disturbed, allowing structural variants to persist and contribute to disease progression and failure of regeneration. Here, we discuss first how fibronectin helps tissue regeneration, with a focus on normal cutaneous wound healing as an example of complete tissue recovery. Then, we continue to argue that, although the fibronectin matrix generated following cartilage and central nervous system white matter (myelin) injury initially benefits regeneration, fibronectin clearance is incomplete in chronic wounds (skin), osteoarthritis (cartilage), and multiple sclerosis (myelin). Fibronectin fragments or aggregates persist, which impair tissue regeneration. The similarities in fibronectin-mediated mechanisms of frustrated regeneration indicate that complete fibronectin clearance is a prerequisite for recovery in any tissue. Also, they provide common targets for developing therapeutic strategies in regenerative medicine.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
Brazil 1 1%
Unknown 82 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 31%
Student > Master 13 15%
Researcher 12 14%
Student > Bachelor 10 12%
Unspecified 7 8%
Other 16 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 30%
Medicine and Dentistry 12 14%
Unspecified 12 14%
Biochemistry, Genetics and Molecular Biology 12 14%
Neuroscience 7 8%
Other 16 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2017.
All research outputs
#7,340,530
of 12,227,808 outputs
Outputs from Cellular & Molecular Life Sciences
#1,704
of 2,527 outputs
Outputs of similar age
#76,683
of 158,407 outputs
Outputs of similar age from Cellular & Molecular Life Sciences
#25
of 49 outputs
Altmetric has tracked 12,227,808 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,527 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 158,407 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.