| Title |
Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis
|
|---|---|
| Published in |
EJNMMI Research, March 2017
|
| DOI | 10.1186/s13550-017-0267-2 |
| Pubmed ID | |
| Authors |
M-S. Buhour, F. Doidy, A. Mondou, A. Pélerin, L. Carluer, F. Eustache, F. Viader, B. Desgranges |
| Abstract |
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease of the nervous system involving both upper and lower motor neurons. The patterns of structural and metabolic brain alterations are still unclear. Several studies using anatomical MRI yielded a number of discrepancies in their results, and a few PET studies investigated the effect of ALS on cerebral glucose metabolism. The aim of this study was threefold: to highlight the patterns of grey matter (GM) atrophy, hypometabolism and hypermetabolism in patients with ALS, then to understand the neurobehavioral significance of hypermetabolism and, finally, to investigate the regional differences between the morphologic and functional changes in ALS patients, using a specially designed voxel-based method. Thirty-seven patients with ALS and 37 age- and sex-matched healthy individuals underwent both structural MRI and (18)[F]-fluorodeoxyglucose (FDG) PET examinations. PET data were corrected for partial volume effects. Structural and metabolic abnormalities were examined in ALS patients compared with control subjects using two-sample t tests in statistical parametric mapping (SPM). Then, we extracted the metabolic values of clusters presenting hypermetabolism to correlate with selected cognitive scores. Finally, GM atrophy and hypometabolism patterns were directly compared with a one-paired t test in SPM. We found GM atrophy as well as hypometabolism in motor and extra motor regions and hypermetabolism in medial temporal lobe and cerebellum. We observed negative correlations between the metabolism of the right and left parahippocampal gyri and episodic memory and between the metabolism of right temporal pole and cognitive theory of mind. GM atrophy predominated in the temporal pole, left hippocampus and right thalamus, while hypometabolism predominated in a single cluster in the left frontal superior medial cortex. Our findings provide direct evidence of regional variations in the hierarchy and relationships between GM atrophy and hypometabolism in ALS. Moreover, the (18)FDG-PET investigation suggests that cerebral hypermetabolism is deleterious to cognitive function in ALS. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 58 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 22% |
| Student > Master | 10 | 17% |
| Researcher | 7 | 12% |
| Student > Doctoral Student | 5 | 9% |
| Student > Bachelor | 4 | 7% |
| Other | 5 | 9% |
| Unknown | 14 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 19% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Medicine and Dentistry | 6 | 10% |
| Psychology | 3 | 5% |
| Physics and Astronomy | 2 | 3% |
| Other | 8 | 14% |
| Unknown | 22 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2017.
All research outputs
#4,209,783
of 22,958,253 outputs
Outputs from EJNMMI Research
#54
of 563 outputs
Outputs of similar age
#76,088
of 311,212 outputs
Outputs of similar age from EJNMMI Research
#3
of 11 outputs
Altmetric has tracked 22,958,253 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 563 research outputs from this source. They receive a mean Attention Score of 2.5. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,212 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.