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Galactose-α-1,3-Galactose: Atypical Food Allergen or Model IgE Hypersensitivity?

Overview of attention for article published in Current Allergy and Asthma Reports, February 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

twitter
2 tweeters

Citations

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14 Dimensions

Readers on

mendeley
21 Mendeley
Title
Galactose-α-1,3-Galactose: Atypical Food Allergen or Model IgE Hypersensitivity?
Published in
Current Allergy and Asthma Reports, February 2017
DOI 10.1007/s11882-017-0672-7
Pubmed ID
Authors

Jeffrey M. Wilson, Alexander J. Schuyler, Nikhila Schroeder, Thomas A. E. Platts-Mills

Abstract

Galactose-α-1,3-galactose (α-gal) is a carbohydrate allergen with several unique characteristics. In this article, we discuss some recent advances in our understanding of the 'alpha-gal syndrome,' highlight data supporting the role of ticks in pathogenesis, and speculate on immune mechanisms that lead to sensitization. First described as the target of IgE in individuals suffering immediate hypersensitivity reactions to the novel anti-EGF monoclonal antibody cetuximab, it is now clear that α-gal sensitization is associated with mammalian meat allergy as well as reactions to other mammalian products. Unlike traditional IgE-mediated food allergies, reactions to α-gal often do not manifest until several hours following an exposure, although co-factors can influence the presentation. Multiple pieces of evidence, including recent work with a mouse model, point to the fact that sensitization is mediated by exposure to certain hard ticks and increasingly we are aware of its globally widespread impact. The oligosaccharide α-gal represents a novel allergen with several unusual clinical features. It has been recognized now on multiple continents and its clinical presentation can be quite variable. Moreover, efforts to delineate the mechanisms leading to α-gal sensitization may have ramifications for our broader understanding of type 2 immunity.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Unspecified 5 24%
Student > Ph. D. Student 5 24%
Other 4 19%
Student > Master 2 10%
Student > Postgraduate 1 5%
Other 4 19%
Readers by discipline Count As %
Medicine and Dentistry 5 24%
Unspecified 5 24%
Biochemistry, Genetics and Molecular Biology 4 19%
Immunology and Microbiology 3 14%
Agricultural and Biological Sciences 2 10%
Other 2 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2017.
All research outputs
#7,256,231
of 13,445,103 outputs
Outputs from Current Allergy and Asthma Reports
#342
of 643 outputs
Outputs of similar age
#115,904
of 258,356 outputs
Outputs of similar age from Current Allergy and Asthma Reports
#6
of 15 outputs
Altmetric has tracked 13,445,103 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 643 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,356 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.