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Repeated doses of cardiac mesenchymal cells are therapeutically superior to a single dose in mice with old myocardial infarction

Overview of attention for article published in Basic Research in Cardiology, February 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

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6 tweeters

Citations

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44 Dimensions

Readers on

mendeley
37 Mendeley
Title
Repeated doses of cardiac mesenchymal cells are therapeutically superior to a single dose in mice with old myocardial infarction
Published in
Basic Research in Cardiology, February 2017
DOI 10.1007/s00395-017-0606-5
Pubmed ID
Authors

Yiru Guo, Marcin Wysoczynski, Yibing Nong, Alex Tomlin, Xiaoping Zhu, Anna M. Gumpert, Marjan Nasr, Senthikumar Muthusamy, Hong Li, Michael Book, Abdur Khan, Kyung U. Hong, Qianhong Li, Roberto Bolli

Abstract

We have recently demonstrated that repeated administrations of c-kit(POS) cardiac progenitor cells (CPCs) have cumulative beneficial effects in rats with old myocardial infarction (MI), resulting in markedly greater improvement in left ventricular (LV) function compared with a single administration. To determine whether this paradigm applies to other species and cell types, mice with a 3-week-old MI received one or three doses of cardiac mesenchymal cells (CMCs), a novel cell type that we have recently described. CMCs or vehicle were infused percutaneously into the LV cavity, 14 days apart. Compared with vehicle-treated mice, the single-dose group exhibited improved LV ejection fraction (EF) after the 1st infusion (consisting of CMCs) but not after the 2nd and 3rd (vehicle). In contrast, in the multiple-dose group, LV EF improved after each CMC infusion, so that at the end of the study, LV EF averaged 35.5 ± 0.7% vs. 32.7 ± 0.6% in the single-dose group (P < 0.05). The multiple-dose group also exhibited less collagen in the non-infarcted region vs. the single-dose group. Engraftment and differentiation of CMCs were negligible in both groups, indicating paracrine effects. These results demonstrate that, in mice with ischemic cardiomyopathy, the beneficial effects of three doses of CMCs are significantly greater than those of one dose, supporting the concept that multiple treatments are necessary to properly evaluate the full therapeutic potential of cell therapy. Thus, the repeated-treatment paradigm is not limited to c-kit (POS) CPCs or to rats, but applies to other cell types and species. The generalizability of this concept dramatically augments its significance.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 32%
Unspecified 5 14%
Researcher 5 14%
Student > Master 4 11%
Student > Bachelor 4 11%
Other 7 19%
Readers by discipline Count As %
Medicine and Dentistry 10 27%
Unspecified 10 27%
Agricultural and Biological Sciences 7 19%
Biochemistry, Genetics and Molecular Biology 4 11%
Engineering 3 8%
Other 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2017.
All research outputs
#3,705,606
of 9,116,047 outputs
Outputs from Basic Research in Cardiology
#66
of 223 outputs
Outputs of similar age
#99,408
of 255,376 outputs
Outputs of similar age from Basic Research in Cardiology
#2
of 6 outputs
Altmetric has tracked 9,116,047 research outputs across all sources so far. This one has received more attention than most of these and is in the 59th percentile.
So far Altmetric has tracked 223 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,376 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.