Problems with using mechanisms to solve the problem of extrapolation

@PietroGhezzi @PhilSciJournal Yes! The stability problem is just one reason to be wary of mechanisms in EBM/EBM+. Another great Howick paper is this one: https://t.co/e04RxBeU5G

Yep. Mechanistic reasoning is tough — https://t.co/umcz0vs9Fw @JRayFalvey @Dr_Ridge_DPT @ElinaG_PT

#EvidenceLive we need to live with much more uncertainty about treatments, even if it has been 'proven' in RCTs http://t.co/eIRSYIcS5O

#EvidenceLive we need to live with much more uncertainty about treatments, even if it has been 'proven' in RCTs http://t.co/eIRSYIcS5O

#EvidenceLive we need to live with much more uncertainty about treatments, even if it has been 'proven' in RCTs http://t.co/eIRSYIcS5O

#EvidenceLive we need to live with much more uncertainty about treatments, even if it has been 'proven' in RCTs http://t.co/eIRSYIcS5O

Problems with using mechanisms to solve the problem of extrapolation http://t.co/Mv12gJuYEP

#EvidenceLive we need to live with much more uncertainty about treatments, even if it has been 'proven' in RCTs http://t.co/eIRSYIcS5O

#EvidenceLive we need to live with much more uncertainty about treatments, even if it has been 'proven' in RCTs http://t.co/eIRSYIcS5O

@trishgreenhalgh we need to live with much more uncertainty about treatments, even if it has been 'proven' in RCTs http://t.co/eIRSYIcS5O

Problems with using mechanisms to solve the problem of extrapolation http://t.co/h1Llx5iqdy #researchmethods

Problems with using #mechanisms to solve the problem of extrapolation - Howick, Glasziou, Aronson -- http://t.co/nvUaTFmqJW #philmed