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Impact of PET acquisition durations on image quality and lesion detectability in whole-body 68Ga-PSMA PET-MRI

Overview of attention for article published in EJNMMI Research, February 2017
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Title
Impact of PET acquisition durations on image quality and lesion detectability in whole-body 68Ga-PSMA PET-MRI
Published in
EJNMMI Research, February 2017
DOI 10.1186/s13550-017-0261-8
Pubmed ID
Authors

Benjamin Noto, Florian Büther, Katharina Auf der Springe, Nemanja Avramovic, Walter Heindel, Michael Schäfers, Thomas Allkemper, Lars Stegger

Abstract

While (68)Ga-PSMA PET-MRI might be superior to PET-CT with regard to soft tissue assessment in prostate cancer evaluation, it is also known to potentially introduce additional PET image artefacts. Therefore, the impact of PET acquisition duration and attenuation data on artefact occurrence, lesion detectability, and quantification was investigated. To this end, whole-body PET list mode data from 12 patients with prostate cancer were acquired 1 h after injection of 2 MBq/kg [(68)Ga]HBED-CC-PSMA on a hybrid PET-MRI system. List mode data were further transformed into data sets representing 300, 180, 90, and 30 s acquisition duration per bed position. Standard attenuation and scatter corrections were performed based on MRI-derived attenuation maps, complemented by emission-based attenuation data in areas not covered by MRI. A total of 288 image data sets were reconstructed with varying acquisition durations for emission and attenuation data with and without scatter and prompt gamma correction, and further analysed regarding image quality and diagnostic performance. Decreased PET acquisition durations resulted in a significantly increased incidence of halo artefacts around kidneys and bladder, decreased lesion detectability and lower SUV as well as markedly lower arm attenuation values: Halo artefacts were present in 5 out of 12 cases at 300-s duration, in 6 at 180 s, in 10 at 90 s, and in 11 cases at 30 s. Using attenuation data of the 300 s scans restored artefact occurrence to the original 300-s level. Prompt gamma correction only led to small improvements in terms of artefact occurrence and size. Of the 141 detected lesions in the 300-s images one lesion was not detected at 180 s, 28 at 90 s, and 64 at 30 s. Using the 300-s attenuation map decreased non-detectability of lesions to zero at 180 s, 9 at 90 s, and 52 at 30 s. Attenuation maps at 90 and 30 s demonstrated markedly lower mean arm attenuation values (0.002 cm(-1)) than those at 300 s (0.084 cm(-1)), and 180 s (0.062 cm(-1)). Short acquisition durations of less than 3 minutes per bed position result in unacceptable image artefacts and decreased diagnostic performance in current whole-body (68)Ga-PSMA PET-MRI and should be avoided. Increased image noise and imperfections in generated attenuation maps were identified as a paramount cause for image degradation.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 30%
Student > Bachelor 4 10%
Student > Ph. D. Student 3 8%
Professor > Associate Professor 3 8%
Student > Master 3 8%
Other 8 20%
Unknown 7 18%
Readers by discipline Count As %
Medicine and Dentistry 15 38%
Physics and Astronomy 6 15%
Nursing and Health Professions 5 13%
Engineering 3 8%
Economics, Econometrics and Finance 1 3%
Other 3 8%
Unknown 7 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2017.
All research outputs
#7,840,541
of 9,045,973 outputs
Outputs from EJNMMI Research
#120
of 194 outputs
Outputs of similar age
#258,475
of 312,213 outputs
Outputs of similar age from EJNMMI Research
#6
of 7 outputs
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So far Altmetric has tracked 194 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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