| Title |
No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease in nine ADHD candidate SNPs
|
|---|---|
| Published in |
ADHD Attention Deficit and Hyperactivity Disorders, February 2017
|
| DOI | 10.1007/s12402-017-0219-8 |
| Pubmed ID | |
| Authors |
Julia M. Geissler, International Parkinson Disease Genomics Consortium members, Marcel Romanos, Manfred Gerlach, Daniela Berg, Claudia Schulte |
| Abstract |
Attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease (PD) involve pathological changes in brain structures such as the basal ganglia, which are essential for the control of motor and cognitive behavior and impulsivity. The cause of ADHD and PD remains unknown, but there is increasing evidence that both seem to result from a complicated interplay of genetic and environmental factors affecting numerous cellular processes and brain regions. To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal-associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13). Information was extracted from a recent meta-analysis of five genome-wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed. No significant association was observed after correction for multiple testing. Therefore, it is reasonable to conclude that candidate variants implicated in the pathogenesis of ADHD do not play a substantial role in PD. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 79 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 16% |
| Student > Bachelor | 9 | 11% |
| Student > Ph. D. Student | 7 | 9% |
| Researcher | 6 | 8% |
| Professor | 6 | 8% |
| Other | 22 | 28% |
| Unknown | 17 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 15 | 19% |
| Medicine and Dentistry | 15 | 19% |
| Psychology | 10 | 13% |
| Agricultural and Biological Sciences | 4 | 5% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Other | 11 | 14% |
| Unknown | 21 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2019.
All research outputs
#2,224,823
of 25,882,826 outputs
Outputs from ADHD Attention Deficit and Hyperactivity Disorders
#27
of 184 outputs
Outputs of similar age
#44,851
of 427,911 outputs
Outputs of similar age from ADHD Attention Deficit and Hyperactivity Disorders
#2
of 10 outputs
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So far Altmetric has tracked 184 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has done well, scoring higher than 85% of its peers.
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We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.