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Neuroprotective and Anti-inflammatory Activities of Ketogenic Diet on MPTP-induced Neurotoxicity

Overview of attention for article published in Journal of Molecular Neuroscience, March 2010
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2 Facebook pages
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2 video uploaders

Citations

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53 Dimensions

Readers on

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76 Mendeley
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4 CiteULike
Title
Neuroprotective and Anti-inflammatory Activities of Ketogenic Diet on MPTP-induced Neurotoxicity
Published in
Journal of Molecular Neuroscience, March 2010
DOI 10.1007/s12031-010-9336-y
Pubmed ID
Authors

Xinxin Yang, Baohua Cheng

Abstract

Ketogenic diet (KD) is a high-fat, low-protein and low-carbohydrate diet. It is reported that KD can provide the neuroprotection for the neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD) and amyotrophic lateral sclerosis. The main clinical symptom of PD is motor dysfunction derived from the loss of dopaminergic neurons in the substantia nigra (SN) and dopamine content in the striatum subsequently. It is well known that treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice produce motor dysfunction, biochemical, and neurochemical changes remarkably similar to idiopathic PD patients. In this study, we investigated the neuroprotective and anti-inflammatory effects of KD in MPTP-treated mice. The data showed that pretreatment with KD alleviated the motor dysfunction induced by MPTP. The decrease of Nissl-staining and tyrosine hydroxylase (TH)-positive neurons induced by MPTP was inhibited in the SN. The change of dopamine was very similar to dopaminergic neurons in the SN. KD inhibited the activation of microglia induced by MPTP in the SN. The levels of proinflammatory cytokines (interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha) in the SN were also decreased and induced by MPTP. So, we concluded that KD was neuroprotective and anti-inflammatory against MPTP-neurotoxicity.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 5%
India 1 1%
Unknown 71 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 25%
Student > Bachelor 14 18%
Student > Ph. D. Student 12 16%
Unspecified 7 9%
Student > Doctoral Student 6 8%
Other 18 24%
Readers by discipline Count As %
Medicine and Dentistry 22 29%
Agricultural and Biological Sciences 16 21%
Unspecified 12 16%
Neuroscience 12 16%
Psychology 4 5%
Other 10 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2018.
All research outputs
#7,322,203
of 11,753,665 outputs
Outputs from Journal of Molecular Neuroscience
#488
of 886 outputs
Outputs of similar age
#71,581
of 137,493 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#6
of 18 outputs
Altmetric has tracked 11,753,665 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 886 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 137,493 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.