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Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult

Overview of attention for article published in Acta Neuropathologica, December 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

twitter
18 tweeters
facebook
4 Facebook pages

Citations

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81 Dimensions

Readers on

mendeley
116 Mendeley
Title
Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult
Published in
Acta Neuropathologica, December 2010
DOI 10.1007/s00401-010-0783-x
Pubmed ID
Authors

Andrew P. Mizisin, Ananda Weerasuriya

Abstract

The endoneurial microenvironment, delimited by the endothelium of endoneurial vessels and a multi-layered ensheathing perineurium, is a specialized milieu intérieur within which axons, associated Schwann cells and other resident cells of peripheral nerves function. The endothelium and perineurium restricts as well as regulates exchange of material between the endoneurial microenvironment and the surrounding extracellular space and thus is more appropriately described as a blood-nerve interface (BNI) rather than a blood-nerve barrier (BNB). Input to and output from the endoneurial microenvironment occurs via blood-nerve exchange and convective endoneurial fluid flow driven by a proximo-distal hydrostatic pressure gradient. The independent regulation of the endothelial and perineurial components of the BNI during development, aging and in response to trauma is consistent with homeostatic regulation of the endoneurial microenvironment. Pathophysiological alterations of the endoneurium in experimental allergic neuritis (EAN), and diabetic and lead neuropathy are considered to be perturbations of endoneurial homeostasis. The interactions of Schwann cells, axons, macrophages, and mast cells via cell-cell and cell-matrix signaling regulate the permeability of this interface. A greater knowledge of the dynamic nature of tight junctions and the factors that induce and/or modulate these key elements of the BNI will increase our understanding of peripheral nerve disorders as well as stimulate the development of therapeutic strategies to treat these disorders.

Twitter Demographics

The data shown below were collected from the profiles of 18 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 3%
Germany 1 <1%
India 1 <1%
Unknown 110 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 19%
Student > Master 21 18%
Student > Ph. D. Student 20 17%
Unspecified 11 9%
Other 8 7%
Other 34 29%
Readers by discipline Count As %
Medicine and Dentistry 35 30%
Agricultural and Biological Sciences 21 18%
Neuroscience 18 16%
Unspecified 15 13%
Engineering 9 8%
Other 18 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2015.
All research outputs
#1,121,997
of 13,352,588 outputs
Outputs from Acta Neuropathologica
#215
of 1,661 outputs
Outputs of similar age
#14,505
of 152,677 outputs
Outputs of similar age from Acta Neuropathologica
#3
of 16 outputs
Altmetric has tracked 13,352,588 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,661 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 152,677 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.