| Title |
Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients
|
|---|---|
| Published in |
EJNMMI Research, January 2017
|
| DOI | 10.1186/s13550-016-0248-x |
| Pubmed ID | |
| Authors |
Manon N. G. J. A. Braat, Hugo W. de Jong, Beatrijs A. Seinstra, Mike V. Scholten, Maurice A. A. J. van den Bosch, Marnix G. E. H. Lam |
| Abstract |
Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improve patient selection and treatment planning. A case series will be presented to illustrate the potential of this technique. Hepatocellular carcinoma patients with cirrhosis (Child-Pugh A and B) underwent hepatobiliary scintigraphy pre- and 3 months post-radioembolization as part of a prospective study protocol, which was prematurely terminated because of limited accrual. Included patients were analysed together with their clinical, laboratory and treatment data. Pretreatment-corrected (99m)Tc-mebrofenin liver uptake rates were marginal (1.8-3.0%/min/m(2)), despite acceptable clinical and laboratory parameters. Posttreatment liver functions seriously declined (corrected (99m)Tc-mebrofenin liver uptake rates: 0.6-2.4%/min/m(2)), resulting in lethal radioembolization-induced liver disease in two out of three patients. Hepatobiliary scintigraphy may be of added value during work-up for radioembolization, to estimate liver function reserve and its segmental distribution, especially in patients with underlying cirrhosis, for whom analysis of clinical and laboratory parameters may not be sufficient. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 19% |
| Student > Master | 3 | 10% |
| Student > Doctoral Student | 3 | 10% |
| Researcher | 3 | 10% |
| Other | 2 | 6% |
| Other | 6 | 19% |
| Unknown | 8 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 39% |
| Physics and Astronomy | 4 | 13% |
| Engineering | 3 | 10% |
| Business, Management and Accounting | 2 | 6% |
| Nursing and Health Professions | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 8 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2017.
All research outputs
#15,437,553
of 22,947,506 outputs
Outputs from EJNMMI Research
#260
of 562 outputs
Outputs of similar age
#256,871
of 421,147 outputs
Outputs of similar age from EJNMMI Research
#9
of 18 outputs
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