| Title |
Trichuris suis ova in relapsing-remitting multiple sclerosis and clinically isolated syndrome (TRIOMS): study protocol for a randomized controlled trial
|
|---|---|
| Published in |
Trials, April 2013
|
| DOI | 10.1186/1745-6215-14-112 |
| Pubmed ID | |
| Authors |
Berit Rosche, Klaus-Dieter Wernecke, Stephanie Ohlraun, Jan-Markus Dörr, Friedemann Paul |
| Abstract |
Trichuris suis ova is a probiotic treatment based on the hygiene hypothesis. It has been demonstrated as safe and effective in autoimmune inflammatory bowel diseases and clinical trials indicate that helminth infections also have an immunomodulatory effect in multiple sclerosis.We hypothesize that administering 2,500 Trichuris suis ova eggs orally every two weeks for 12 months is--due to its immunomodulatory and anti-inflammatory effect--significantly more effective than oral placebo in preventing new T2 and Gd+ lesions, as quantified by cerebral MRI and clinical examination, in relapsing-remitting multiple sclerosis and clinically isolated syndrome. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 1 | <1% |
| Germany | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 127 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 15% |
| Researcher | 18 | 14% |
| Student > Ph. D. Student | 17 | 13% |
| Student > Master | 16 | 12% |
| Other | 13 | 10% |
| Other | 28 | 22% |
| Unknown | 19 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 49 | 38% |
| Biochemistry, Genetics and Molecular Biology | 17 | 13% |
| Agricultural and Biological Sciences | 10 | 8% |
| Immunology and Microbiology | 7 | 5% |
| Neuroscience | 7 | 5% |
| Other | 18 | 14% |
| Unknown | 22 | 17% |