↓ Skip to main content

Airway mucus, inflammation and remodeling: emerging links in the pathogenesis of chronic lung diseases

Overview of attention for article published in Cell and Tissue Research, January 2017
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

policy
1 policy source
twitter
8 X users
patent
1 patent

Citations

dimensions_citation
137 Dimensions

Readers on

mendeley
167 Mendeley
Title
Airway mucus, inflammation and remodeling: emerging links in the pathogenesis of chronic lung diseases
Published in
Cell and Tissue Research, January 2017
DOI 10.1007/s00441-016-2562-z
Pubmed ID
Authors

Zhe Zhou-Suckow, Julia Duerr, Matthias Hagner, Raman Agrawal, Marcus A. Mall

Abstract

Airway mucus obstruction is a hallmark of many chronic lung diseases including rare genetic disorders such as cystic fibrosis (CF) and primary ciliary dyskinesia, as well as common lung diseases such as asthma and chronic obstructive pulmonary disease (COPD), which have emerged as a leading cause of morbidity and mortality worldwide. However, the role of excess airway mucus in the in vivo pathogenesis of these diseases remains poorly understood. The generation of mice with airway-specific overexpression of epithelial Na(+) channels (ENaC), exhibiting airway surface dehydration (mucus hyperconcentration), impaired mucociliary clearance (MCC) and mucus plugging, led to a model of muco-obstructive lung disease that shares key features of CF and COPD. In this review, we summarize recent progress in the understanding of causes of impaired MCC and in vivo consequences of airway mucus obstruction that can be inferred from studies in βENaC-overexpressing mice. These studies confirm that mucus hyperconcentration on airway surfaces plays a critical role in the pathophysiology of impaired MCC, mucus adhesion and airway plugging that cause airflow obstruction and provide a nidus for bacterial infection. In addition, these studies support the emerging concept that excess airway mucus per se, probably via several mechanisms including hypoxic epithelial necrosis, retention of inhaled irritants or allergens, and potential immunomodulatory effects, is a potent trigger of chronic airway inflammation and associated lung damage, even in the absence of bacterial infection. Finally, these studies suggest that improvement of mucus clearance may be a promising therapeutic strategy for a spectrum of muco-obstructive lung diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Canada 1 <1%
Unknown 165 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 17%
Researcher 26 16%
Student > Bachelor 24 14%
Student > Master 20 12%
Professor 8 5%
Other 31 19%
Unknown 30 18%
Readers by discipline Count As %
Medicine and Dentistry 29 17%
Biochemistry, Genetics and Molecular Biology 26 16%
Agricultural and Biological Sciences 21 13%
Immunology and Microbiology 16 10%
Engineering 9 5%
Other 26 16%
Unknown 40 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2022.
All research outputs
#3,004,954
of 24,643,522 outputs
Outputs from Cell and Tissue Research
#78
of 2,204 outputs
Outputs of similar age
#59,277
of 426,499 outputs
Outputs of similar age from Cell and Tissue Research
#3
of 17 outputs
Altmetric has tracked 24,643,522 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,204 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 426,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.