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Airway mucus, inflammation and remodeling: emerging links in the pathogenesis of chronic lung diseases

Overview of attention for article published in Cell & Tissue Research, January 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

twitter
2 tweeters
patent
1 patent

Citations

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51 Dimensions

Readers on

mendeley
109 Mendeley
Title
Airway mucus, inflammation and remodeling: emerging links in the pathogenesis of chronic lung diseases
Published in
Cell & Tissue Research, January 2017
DOI 10.1007/s00441-016-2562-z
Pubmed ID
Authors

Zhe Zhou-Suckow, Julia Duerr, Matthias Hagner, Raman Agrawal, Marcus A. Mall

Abstract

Airway mucus obstruction is a hallmark of many chronic lung diseases including rare genetic disorders such as cystic fibrosis (CF) and primary ciliary dyskinesia, as well as common lung diseases such as asthma and chronic obstructive pulmonary disease (COPD), which have emerged as a leading cause of morbidity and mortality worldwide. However, the role of excess airway mucus in the in vivo pathogenesis of these diseases remains poorly understood. The generation of mice with airway-specific overexpression of epithelial Na(+) channels (ENaC), exhibiting airway surface dehydration (mucus hyperconcentration), impaired mucociliary clearance (MCC) and mucus plugging, led to a model of muco-obstructive lung disease that shares key features of CF and COPD. In this review, we summarize recent progress in the understanding of causes of impaired MCC and in vivo consequences of airway mucus obstruction that can be inferred from studies in βENaC-overexpressing mice. These studies confirm that mucus hyperconcentration on airway surfaces plays a critical role in the pathophysiology of impaired MCC, mucus adhesion and airway plugging that cause airflow obstruction and provide a nidus for bacterial infection. In addition, these studies support the emerging concept that excess airway mucus per se, probably via several mechanisms including hypoxic epithelial necrosis, retention of inhaled irritants or allergens, and potential immunomodulatory effects, is a potent trigger of chronic airway inflammation and associated lung damage, even in the absence of bacterial infection. Finally, these studies suggest that improvement of mucus clearance may be a promising therapeutic strategy for a spectrum of muco-obstructive lung diseases.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Canada 1 <1%
Unknown 107 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 20%
Researcher 18 17%
Student > Bachelor 14 13%
Student > Master 11 10%
Student > Doctoral Student 7 6%
Other 22 20%
Unknown 15 14%
Readers by discipline Count As %
Medicine and Dentistry 22 20%
Biochemistry, Genetics and Molecular Biology 19 17%
Agricultural and Biological Sciences 15 14%
Immunology and Microbiology 10 9%
Nursing and Health Professions 6 6%
Other 15 14%
Unknown 22 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2018.
All research outputs
#3,574,717
of 13,633,853 outputs
Outputs from Cell & Tissue Research
#208
of 1,638 outputs
Outputs of similar age
#102,808
of 346,616 outputs
Outputs of similar age from Cell & Tissue Research
#6
of 31 outputs
Altmetric has tracked 13,633,853 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,638 research outputs from this source. They receive a mean Attention Score of 2.6. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,616 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.