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Skeletal-related events and prognosis in urothelial cancer patients with bone metastasis

Overview of attention for article published in International Journal of Clinical Oncology, January 2017
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Title
Skeletal-related events and prognosis in urothelial cancer patients with bone metastasis
Published in
International Journal of Clinical Oncology, January 2017
DOI 10.1007/s10147-016-1075-9
Pubmed ID
Authors

Yusuke Tsuda, Tohru Nakagawa, Yusuke Shinoda, Atsushi Kanatani, Taketo Kawai, Satoru Taguchi, Yukio Yamada, Ryoko Sawada, Haruki Kume, Yukio Homma, Sakae Tanaka, Hirotaka Kawano

Abstract

The aim of the present study was to elucidate the details of bone metastasis (BM) and the resulting skeletal-related events (SREs), and survival and prognostic factors, in urothelial cancer (UC) patients with BM. A total of 48 UC patients with BM who were treated at our institution between 1994 and 2013 were enrolled. Details of BM and SREs were investigated. The Kaplan-Meier method was used to estimate survival duration. Relationships between several clinical features and survival were analyzed using the log-rank test and the Cox hazard model. Of the 48 patients, 39 (81.3%) were male, with a median age at diagnosis of BM of 68 years [interquartile range (IQR), 61-75 years]. Frequent metastatic sites included the pelvis (31 patients, 64.6%) and spine (28, 58.3%). SREs occurred in 31 patients (64.6%) at a median duration of 0.9 months (IQR, 0.3-5.4 months) after diagnosis of BM, including radiation therapy (n = 23; 74.2%), spinal cord compression (n = 4; 12.9%), pathological fracture (n = 3; 9.7%) and hypercalcemia (n = 1; 3.2%). Median overall survival periods after diagnosis of BM and SREs were 6.2 and 5.6 months, respectively. On multivariate analysis, factors significantly associated with survival after BM were performance status [hazard ratio (HR) for ≥2 vs. 0-1, 4.94; P = 0.0003], liver metastasis (HR, 4.08; P = 0.0018), chemotherapy after BM (HR, 0.31; P = 0.0018), and use of bone-modifying agents (HR, 0.36; P = 0.0147). We revealed clinicopathological factors that are predictive of prognosis of UC patients with BM. Although the prognosis is poor, chemotherapy and bone-modifying agents may confer survival benefits.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 5 31%
Student > Doctoral Student 3 19%
Student > Master 1 6%
Student > Bachelor 1 6%
Lecturer 1 6%
Other 5 31%
Readers by discipline Count As %
Unspecified 6 38%
Medicine and Dentistry 5 31%
Nursing and Health Professions 3 19%
Sports and Recreations 1 6%
Engineering 1 6%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2017.
All research outputs
#6,817,200
of 8,945,878 outputs
Outputs from International Journal of Clinical Oncology
#376
of 679 outputs
Outputs of similar age
#219,439
of 308,020 outputs
Outputs of similar age from International Journal of Clinical Oncology
#3
of 5 outputs
Altmetric has tracked 8,945,878 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 679 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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