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Cohesin complexes with a potential to link mammalian meiosis to cancer

Overview of attention for article published in Cell Regeneration, January 2013
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About this Attention Score

  • Among the highest-scoring outputs from this source (#31 of 118)
  • Above-average Attention Score compared to outputs of the same age (51st percentile)

Mentioned by

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6 tweeters

Citations

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12 Dimensions

Readers on

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34 Mendeley
Title
Cohesin complexes with a potential to link mammalian meiosis to cancer
Published in
Cell Regeneration, January 2013
DOI 10.1186/2045-9769-2-4
Pubmed ID
Authors

Alexander Strunnikov

Abstract

Among multiple genes aberrantly activated in cancers, invariably, there is a group related to the capacity of cell to self-renewal. Some of these genes are related to the normal process of development, including the establishment of a germline. This group, a part of growing family of Cancer/Testis (CT) genes, now includes the meiosis specific subunits of cohesin complex. The first reports characterizing the SMC1 and RAD21 genes, encoding subunits of cohesin, were published 20 years ago; however the exact molecular mechanics of cohesin molecular machine in vivo remains rather obscure notwithstanding ample elegant experiments. The matters are complicated by the fact that the evolution of cohesin function, which is served by just two basic types of protein complexes in budding yeast, took an explosive turn in Metazoa. The recent characterization of a new set of genes encoding cohesin subunits specific for meiosis in vertebrates adds several levels of complexity to the task of structure-function analysis of specific cohesin pathways, even more so in relation to their aberrant functionality in cancers. These three proteins, SMC1β, RAD21L and STAG3 are likely involved in a specific function in the first meiotic prophase, genetic recombination, and segregation of homologues. However, at present, it is rather challenging to pinpoint the molecular role of these proteins, particularly in synaptonemal complex or centromere function, due to the multiplicity of different cohesins in meiosis. The roles of these proteins in cancer cell physiology, upon their aberrant activation in tumors, also remain to be elucidated. Nevertheless, as the existence of Cancer/Testis cohesin complexes in tumor cells appears to be all but certain, this brings a promise of a new target for cancer therapy and/or diagnostics.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Lithuania 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 21%
Researcher 6 18%
Student > Ph. D. Student 6 18%
Student > Bachelor 3 9%
Professor > Associate Professor 3 9%
Other 4 12%
Unknown 5 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 35%
Agricultural and Biological Sciences 10 29%
Chemistry 3 9%
Business, Management and Accounting 1 3%
Medicine and Dentistry 1 3%
Other 1 3%
Unknown 6 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2019.
All research outputs
#11,557,755
of 20,578,537 outputs
Outputs from Cell Regeneration
#31
of 118 outputs
Outputs of similar age
#82,782
of 172,171 outputs
Outputs of similar age from Cell Regeneration
#1
of 1 outputs
Altmetric has tracked 20,578,537 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 118 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,171 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them