Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

糖尿病になると、ミトコンドリアの機能障害が起こり、酸化的リン酸化及び電子伝達能力が低下すると言われていたが、実はミトコンドリアの機能自体に健常者との違いはなく、糖尿病患者では骨格筋のミトコンドリア含有量が低下していた、という論文。 https://t.co/AS4dJJl6ci

RT @LykkeSylow: Sylow Journal Club October "Link between mitochondria and insulin resistance in muscle?" Missing any essentials? https://t.…

RT @LykkeSylow: Sylow Journal Club October "Link between mitochondria and insulin resistance in muscle?" Missing any essentials? https://t.…

RT @LykkeSylow: Sylow Journal Club October "Link between mitochondria and insulin resistance in muscle?" Missing any essentials? https://t.…

@LykkeSylow mouse IR and poorly controlled/small human biopsy studies covered (mootha/Patti?) 👍🏻 Large scale human muscle analysis (>1,000 samples) adjusted for confounders (age & vo2max) identify AA oxidative catabolism p/w with oxphos unrelated ht

RT @LykkeSylow: Sylow Journal Club October "Link between mitochondria and insulin resistance in muscle?" Missing any essentials? https://t.…

Sylow Journal Club October "Link between mitochondria and insulin resistance in muscle?" Missing any essentials? https://t.co/00HT75T7Q9 https://t.co/w4ShRBiNI1 https://t.co/8FrifXJOi8 https://t.co/9J47mhp8OG https://t.co/lQxoTg5ycV https://t.co/VYl3Peuwur

Type 2 diabetics have normal muscle mito function - but lower mito density.. http://t.co/9Aewm21vxN

Type 2 diabetics have normal muscle mito function - but lower mito density.. http://t.co/9Aewm21vxN