@CaloriesProper @JimJohnsonSci @ESpacetime @martykendall2 @bcorkey @GardnerPhD The order I’d go with is Adipose-> skeletal muscle-> liver. Look at a lack of functional adipose in lipodystrophy to highlight the importance of functional adipose being
@DaleWil39870290 @tednaiman @DrEenfeldt Ah, now we’re getting somewhere. You’re so close. Consider this to answer your question. https://t.co/kbIgAQIooo
It works, but causes a damaging amount of fat storage that results in oxidative stress, inflammation, and insurmountable insulin resistance. As a result, fatty acids begin to leak back into the blood stream, leading to ectopic fat storage. https://t.co/qw
adipose as a buffer for daily lipid flux (classic paper by Frayn) https://t.co/Tdc38Vl1ad #health #nutrition #weight
@MichaelMindrum Not sure I am qualified, but we routinely see poor fat oxidation RER >0.9 often in patients with 'normal' fasting insulin. This can also persist some weeks on an LC diet. Perhaps Frayn's adipose buffer hypothesis still has some legs. ht
RT @raphaels7: Adipose tissue as a buffer for daily lipid flux https://t.co/Bmoas2L60S can recommend
RT @raphaels7: Adipose tissue as a buffer for daily lipid flux https://t.co/Bmoas2L60S can recommend
RT @raphaels7: Adipose tissue as a buffer for daily lipid flux https://t.co/Bmoas2L60S can recommend
RT @raphaels7: Adipose tissue as a buffer for daily lipid flux https://t.co/Bmoas2L60S can recommend
RT @raphaels7: Adipose tissue as a buffer for daily lipid flux https://t.co/Bmoas2L60S can recommend
Adipose tissue as a buffer for daily lipid flux https://t.co/Bmoas2L60S can recommend
@TunisianKeto I don't think it's all due to cortisol. I'm partial to Keith Frayn's thinking. https://t.co/tiimHq5TAG
@GubbSco Yes, several papers explain *why* (or hypothesize as to why) fat builds up in non-adipose organs, including in pancreatic beta cells. https://t.co/tiimHq5TAG
A key to understanding #LCHF and #keto "Adipose tissue as a buffer for daily lipid flux" https://t.co/iaNVCRGGZu
@tednaiman Frayn describesd this very succinctly back in 2002. https://t.co/khbmLyVsGM
RT @izzybandurek: #nssummer18 @NutritionSoc Fantastic presentation from Prof Keith Frayn @UniofOxford on adipose tissue and fatty acid met…
RT @izzybandurek: #nssummer18 @NutritionSoc Fantastic presentation from Prof Keith Frayn @UniofOxford on adipose tissue and fatty acid met…
This was a great talk. Clarified a few things about at metabolism and fantastic illustration of how insulin shuts off fat mobilisation from adipose tissue. #NSsummer18 https://t.co/pdYivmZLgx
#nssummer18 @NutritionSoc Fantastic presentation from Prof Keith Frayn @UniofOxford on adipose tissue and fatty acid metabolism Try these for starters: 🔸 https://t.co/kwSnbrvaPE 🔸https://t.co/Me9ir7TbZ6 #Nutrition #Metabolism #AlwaysLearning https://t.c
Health, diabetes:"a study [90] showed: in obese subjects, adipose tissue LPL will, indeed, respond to a ‘normal’ extent to insulin stimulation, but that this process is considerably delayed compared with lean subjects. Delay = excessive exposure to lipids.
@tednaiman Or, in the liver or kidneys... And then, congratulations, you have type 2 diabetes. https://t.co/tiimHq5TAG