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Glutamic acid promotes monacolin K production and monacolin K biosynthetic gene cluster expression in Monascus

Overview of attention for article published in AMB Express, January 2017
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10 Mendeley
Title
Glutamic acid promotes monacolin K production and monacolin K biosynthetic gene cluster expression in Monascus
Published in
AMB Express, January 2017
DOI 10.1186/s13568-016-0311-z
Pubmed ID
Authors

Chan Zhang, Jian Liang, Le Yang, Shiyuan Chai, Chenxi Zhang, Baoguo Sun, Chengtao Wang

Abstract

This study investigated the effects of glutamic acid on production of monacolin K and expression of the monacolin K biosynthetic gene cluster. When Monascus M1 was grown in glutamic medium instead of in the original medium, monacolin K production increased from 48.4 to 215.4 mg l(-1), monacolin K production increased by 3.5 times. Glutamic acid enhanced monacolin K production by upregulating the expression of mokB-mokI; on day 8, the expression level of mokA tended to decrease by Reverse Transcription-polymerase Chain Reaction. Our findings demonstrated that mokA was not a key gene responsible for the quantity of monacolin K production in the presence of glutamic acid. Observation of Monascus mycelium morphology using Scanning Electron Microscope showed glutamic acid significantly increased the content of Monascus mycelium, altered the permeability of Monascus mycelium, enhanced secretion of monacolin K from the cell, and reduced the monacolin K content in Monascus mycelium, thereby enhancing monacolin K production.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 20%
Student > Doctoral Student 1 10%
Lecturer 1 10%
Other 1 10%
Researcher 1 10%
Other 1 10%
Unknown 3 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 30%
Agricultural and Biological Sciences 3 30%
Business, Management and Accounting 1 10%
Unknown 3 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2017.
All research outputs
#4,811,054
of 8,882,101 outputs
Outputs from AMB Express
#248
of 563 outputs
Outputs of similar age
#168,194
of 301,871 outputs
Outputs of similar age from AMB Express
#22
of 54 outputs
Altmetric has tracked 8,882,101 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 563 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,871 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.