Title |
Presynaptic neuromuscular transmission defect in the stiff person syndrome
|
---|---|
Published in |
BMC Neurology, December 2016
|
DOI | 10.1186/s12883-016-0773-2 |
Pubmed ID | |
Authors |
Y. L. Lo, Y. E. Tan |
Abstract |
The stiff person syndrome (SPS) is a rare disorder characterized by muscular rigidity and stiffness. We describe an SPS patient presenting with longstanding fatigue and electrophysiological evidence of presynaptic neuromuscular transmission defect, who responded to administration of pyridostigmine. In contrast, no electrophysiolgical evidence of neuromuscular transmission defect was demonstrated in 2 other SPS patients without fatigue symptoms. Our findings suggest that glutamic acid decarboxylase (GAD) antibodies may play a role in presynaptic neuromuscular transmission defect of SPS patients with fatigue. |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 4 | 18% |
Professor | 2 | 9% |
Student > Ph. D. Student | 2 | 9% |
Librarian | 1 | 5% |
Student > Master | 1 | 5% |
Other | 2 | 9% |
Unknown | 10 | 45% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 3 | 14% |
Nursing and Health Professions | 2 | 9% |
Medicine and Dentistry | 2 | 9% |
Arts and Humanities | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 0 | 0% |
Unknown | 13 | 59% |
Attention Score in Context
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#20,382,391
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Outputs from BMC Neurology
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Outputs of similar age from BMC Neurology
#38
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