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Understanding brain dysfunction in sepsis

Overview of attention for article published in Annals of Intensive Care, May 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
8 tweeters
facebook
1 Facebook page

Citations

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199 Dimensions

Readers on

mendeley
357 Mendeley
Title
Understanding brain dysfunction in sepsis
Published in
Annals of Intensive Care, May 2013
DOI 10.1186/2110-5820-3-15
Pubmed ID
Authors

Romain Sonneville, Franck Verdonk, Camille Rauturier, Isabelle F Klein, Michel Wolff, Djillali Annane, Fabrice Chretien, Tarek Sharshar

Abstract

Sepsis often is characterized by an acute brain dysfunction, which is associated with increased morbidity and mortality. Its pathophysiology is highly complex, resulting from both inflammatory and noninflammatory processes, which may induce significant alterations in vulnerable areas of the brain. Important mechanisms include excessive microglial activation, impaired cerebral perfusion, blood-brain-barrier dysfunction, and altered neurotransmission. Systemic insults, such as prolonged inflammation, severe hypoxemia, and persistent hyperglycemia also may contribute to aggravate sepsis-induced brain dysfunction or injury. The diagnosis of brain dysfunction in sepsis relies essentially on neurological examination and neurological tests, such as EEG and neuroimaging. A brain MRI should be considered in case of persistent brain dysfunction after control of sepsis and exclusion of major confounding factors. Recent MRI studies suggest that septic shock can be associated with acute cerebrovascular lesions and white matter abnormalities. Currently, the management of brain dysfunction mainly consists of control of sepsis and prevention of all aggravating factors, including metabolic disturbances, drug overdoses, anticholinergic medications, withdrawal syndromes, and Wernicke's encephalopathy. Modulation of microglial activation, prevention of blood-brain-barrier alterations, and use of antioxidants represent relevant therapeutic targets that may impact significantly on neurologic outcomes. In the future, investigations in patients with sepsis should be undertaken to reduce the duration of brain dysfunction and to study the impact of this reduction on important health outcomes, including functional and cognitive status in survivors.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 357 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Brazil 2 <1%
Czechia 1 <1%
Italy 1 <1%
Netherlands 1 <1%
France 1 <1%
United Kingdom 1 <1%
Mexico 1 <1%
Spain 1 <1%
Other 2 <1%
Unknown 344 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 48 13%
Researcher 40 11%
Student > Bachelor 40 11%
Student > Postgraduate 35 10%
Student > Ph. D. Student 35 10%
Other 103 29%
Unknown 56 16%
Readers by discipline Count As %
Medicine and Dentistry 169 47%
Neuroscience 33 9%
Agricultural and Biological Sciences 19 5%
Nursing and Health Professions 18 5%
Immunology and Microbiology 11 3%
Other 41 11%
Unknown 66 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2019.
All research outputs
#3,477,166
of 18,051,940 outputs
Outputs from Annals of Intensive Care
#329
of 835 outputs
Outputs of similar age
#31,798
of 167,127 outputs
Outputs of similar age from Annals of Intensive Care
#6
of 10 outputs
Altmetric has tracked 18,051,940 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 835 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,127 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.