| Title |
Imminent risk of fracture after fracture
|
|---|---|
| Published in |
Osteoporosis International, December 2016
|
| DOI | 10.1007/s00198-016-3868-0 |
| Pubmed ID | |
| Authors |
H. Johansson, K. Siggeirsdóttir, N. C. Harvey, A. Odén, V. Gudnason, E. McCloskey, G Sigurdsson, J. A. Kanis |
| Abstract |
The risk of major osteoporotic fracture (MOF) after a first MOF is increased over the whole duration of follow-up, but the imminent risk is even higher. If the acute increment in risk in the few years following MOF is amenable to therapeutic intervention, then immediate short-term treatments may provide worthwhile clinical dividends in a very cost-effective manner. A history of fracture is a strong risk factor for future fractures. The aim of the present study was to determine whether the predictive value of a past MOF for future MOF changed with time. The study was based on a population-based cohort of 18,872 men and women born between 1907 and 1935. Fractures were documented over 510,265 person-years. An extension of Poisson regression was used to investigate the relationship between the first MOF and the second. All associations were adjusted for age and time since baseline. Five thousand thirty-nine individuals sustained one or more MOFs, of whom 1919 experienced a second MOF. The risk of a second MOF after a first increased by 4% for each year of age (95% CI 1.02-1.06) and was 41% higher for women than men (95% CI 1.25-1.59). The risk of a second MOF was highest immediately after the first fracture and thereafter decreased with time though remained higher than the population risk throughout follow-up. For example, 1 year after the first MOF, the risk of a second fracture was 2.7 (2.4-3.0) fold higher than the population risk. After 10 years, this risk ratio was 1.4 (1.2-1.6). The effect was more marked with increasing age. The risk of MOF after a first MOF is increased over the whole follow-up, but the imminent risk is even higher. If the acute increment in risk in the few years following MOF is amenable to therapeutic intervention, then immediate short-term treatments may provide worthwhile clinical dividends in a very cost-effective manner, particularly in the elderly. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 23% |
| Japan | 1 | 8% |
| Mexico | 1 | 8% |
| France | 1 | 8% |
| Venezuela, Bolivarian Republic of | 1 | 8% |
| Canada | 1 | 8% |
| Australia | 1 | 8% |
| Switzerland | 1 | 8% |
| Netherlands | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 1 | 8% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 77% |
| Scientists | 3 | 23% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 171 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 13% |
| Other | 20 | 12% |
| Student > Ph. D. Student | 19 | 11% |
| Student > Bachelor | 15 | 9% |
| Student > Doctoral Student | 11 | 6% |
| Other | 44 | 26% |
| Unknown | 40 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 72 | 42% |
| Nursing and Health Professions | 10 | 6% |
| Biochemistry, Genetics and Molecular Biology | 8 | 5% |
| Engineering | 4 | 2% |
| Social Sciences | 4 | 2% |
| Other | 21 | 12% |
| Unknown | 52 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 51. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2023.
All research outputs
#781,107
of 24,608,500 outputs
Outputs from Osteoporosis International
#93
of 3,805 outputs
Outputs of similar age
#17,075
of 430,775 outputs
Outputs of similar age from Osteoporosis International
#6
of 68 outputs
Altmetric has tracked 24,608,500 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,805 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 430,775 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.