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The Chronobra identifies prevailing mammary vascularity as a candidate variable in breast cancer post-operative outcome prediction

Overview of attention for article published in SpringerPlus, May 2013
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The Chronobra identifies prevailing mammary vascularity as a candidate variable in breast cancer post-operative outcome prediction
Published in
SpringerPlus, May 2013
DOI 10.1186/2193-1801-2-241
Pubmed ID

Hugh W Simpson, David George, Robert B Sothern, Keith Griffiths


We previously described a menstrual heat cycle of the breast in four groups of women (healthy, family history of breast cancer, benign breast disease, 'cancer-associated') who wore a thermometric brassiere (Chronobra). We now ask if 'breast minus oral temperature', indicating 'breast-associated vascularity', could be associated with breast cancer cell vascular access around different aspects of the menstrual cycle rhythm and survival. Thirty-six pre-menopausal breast cancer patients (average age: 38.97 y) were enrolled consecutively over 15 y and followed for more than 22 y after surgery in order to compare survival and peri-operative vascularity. Each subject wore the Chronobra, which provides an internal bioassay of the vascularity of both breasts, including the operated breast, during 1 h each evening at home for one menstrual cycle, and collected saliva for "free" progesterone to confirm pre-menopausal status and ovulation. Sixty-five healthy age-matched pre-menopausal women served as controls. Both oral and breast temperatures revealed menstrual cycle oscillations, rising just before ovulation until menses onset. Breast-adjusted vascularity also showed menstrual cycle oscillations, with levels differing significantly between the 3 groups during the luteal phase only. At the end of the follow-up span, 18 post-operative breast cancer patients had died from "disseminated" breast cancer and 18 were alive and well. Median follow-up time was 22.6 y for survivors, 6.2 y for non-survivors, and 21.0 y for controls (3 died from diseases unrelated to breast cancer). Based on 'during luteal-phase breast-adjusted vascularity', breast cancer survivors (mean ± SD: -1.65 ± 0.23°C) were significantly hypo-vascular (i.e., -0.23°C cooler) compared with controls (-1.42 ± 0.09°C), while non-survivors (-1.25 ± 0.12°C) were highly significantly hyper-vascular compared with survivors (+0.41°C warmer) and controls (+0.23°C warmer). This suggests that in pre-menopausal breast cancer patients, peri-operative mammary vascularity could offer an outcome test of survival and biologically may be on the "final common pathway" of any tumor to metastatic risk and recurrence.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 18%
Student > Bachelor 2 18%
Researcher 2 18%
Professor 1 9%
Student > Doctoral Student 1 9%
Other 2 18%
Unknown 1 9%
Readers by discipline Count As %
Medicine and Dentistry 7 64%
Biochemistry, Genetics and Molecular Biology 1 9%
Materials Science 1 9%
Agricultural and Biological Sciences 1 9%
Unknown 1 9%

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