| Title |
Antidepressant-like effects of ginsenoside Rg3 in mice via activation of the hippocampal BDNF signaling cascade
|
|---|---|
| Published in |
Journal of Natural Medicines, December 2016
|
| DOI | 10.1007/s11418-016-1066-1 |
| Pubmed ID | |
| Authors |
Zhengchen You, Qi Yao, Jianhong Shen, Zhikai Gu, Hui Xu, Zhonghua Wu, Chuanjun Chen, Luozhu Li |
| Abstract |
Current antidepressants are clinically effective only after several weeks of administration. Ginsenoside Rg3 is one component of ginsenosides, with a similar chemical structure to ginsenoside Rg1. Here, we investigated the antidepressant effects of Rg3 in mouse models of depression. The antidepressant actions of Rg3 were first examined in the forced swim test (FST) and tail suspension test (TST), and then assessed in the chronic social defeat stress (CSDS) model of depression. The changes in the hippocampal brain-derived neurotrophic factor (BDNF) signaling pathway after CSDS and Rg3 treatment were investigated. A tryptophan hydroxylase inhibitor and a BDNF signaling inhibitor were also used to determine the pharmacological mechanisms of Rg3. It was found that Rg3 produced antidepressant effects in the FST and TST without affecting locomotor activity. Rg3 also prevented the CSDS-induced depressive-like symptoms. Moreover, Rg3 fully restored the CSDS-induced decrease in the hippocampal BDNF signaling pathway, and use of the BDNF signaling inhibitor blocked the antidepressant effects of Rg3. In conclusion, ginsenoside Rg3 has antidepressant effects via promotion of the hippocampal BDNF signaling pathway. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 3 | 13% |
| Student > Bachelor | 3 | 13% |
| Other | 2 | 9% |
| Researcher | 2 | 9% |
| Student > Master | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 12 | 52% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 3 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
| Agricultural and Biological Sciences | 1 | 4% |
| Unknown | 17 | 74% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2017.
All research outputs
#18,504,575
of 22,925,760 outputs
Outputs from Journal of Natural Medicines
#303
of 531 outputs
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#309,517
of 419,844 outputs
Outputs of similar age from Journal of Natural Medicines
#4
of 4 outputs
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