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Antidepressant-like effects of ginsenoside Rg3 in mice via activation of the hippocampal BDNF signaling cascade

Overview of attention for article published in Journal of Natural Medicines, December 2016
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Title
Antidepressant-like effects of ginsenoside Rg3 in mice via activation of the hippocampal BDNF signaling cascade
Published in
Journal of Natural Medicines, December 2016
DOI 10.1007/s11418-016-1066-1
Pubmed ID
Authors

Zhengchen You, Qi Yao, Jianhong Shen, Zhikai Gu, Hui Xu, Zhonghua Wu, Chuanjun Chen, Luozhu Li

Abstract

Current antidepressants are clinically effective only after several weeks of administration. Ginsenoside Rg3 is one component of ginsenosides, with a similar chemical structure to ginsenoside Rg1. Here, we investigated the antidepressant effects of Rg3 in mouse models of depression. The antidepressant actions of Rg3 were first examined in the forced swim test (FST) and tail suspension test (TST), and then assessed in the chronic social defeat stress (CSDS) model of depression. The changes in the hippocampal brain-derived neurotrophic factor (BDNF) signaling pathway after CSDS and Rg3 treatment were investigated. A tryptophan hydroxylase inhibitor and a BDNF signaling inhibitor were also used to determine the pharmacological mechanisms of Rg3. It was found that Rg3 produced antidepressant effects in the FST and TST without affecting locomotor activity. Rg3 also prevented the CSDS-induced depressive-like symptoms. Moreover, Rg3 fully restored the CSDS-induced decrease in the hippocampal BDNF signaling pathway, and use of the BDNF signaling inhibitor blocked the antidepressant effects of Rg3. In conclusion, ginsenoside Rg3 has antidepressant effects via promotion of the hippocampal BDNF signaling pathway.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 33%
Other 2 33%
Student > Master 1 17%
Student > Bachelor 1 17%
Readers by discipline Count As %
Unspecified 2 33%
Psychology 2 33%
Agricultural and Biological Sciences 1 17%
Neuroscience 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2017.
All research outputs
#10,760,021
of 13,526,911 outputs
Outputs from Journal of Natural Medicines
#181
of 354 outputs
Outputs of similar age
#262,758
of 374,871 outputs
Outputs of similar age from Journal of Natural Medicines
#2
of 4 outputs
Altmetric has tracked 13,526,911 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 354 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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