| Title |
Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, June 2011
|
| DOI | 10.1007/s10803-011-1314-x |
| Pubmed ID | |
| Authors |
Rabindra Tirouvanziam, Tetyana V. Obukhanych, Julie Laval, Pavel A. Aronov, Robin Libove, Arpita Goswami Banerjee, Karen J. Parker, Ruth O’Hara, Leonard A. Herzenberg, Leonore A. Herzenberg, Antonio Y. Hardan |
| Abstract |
The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD. |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 16% |
| Student > Ph. D. Student | 8 | 14% |
| Other | 7 | 12% |
| Researcher | 6 | 11% |
| Student > Bachelor | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 16 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 25% |
| Agricultural and Biological Sciences | 7 | 12% |
| Psychology | 5 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Social Sciences | 3 | 5% |
| Other | 6 | 11% |
| Unknown | 18 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2011.
All research outputs
#5,953,206
of 23,867,274 outputs
Outputs from Journal of Autism and Developmental Disorders
#2,161
of 5,240 outputs
Outputs of similar age
#32,338
of 117,848 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#16
of 42 outputs
Altmetric has tracked 23,867,274 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,240 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 117,848 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.