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Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders

Overview of attention for article published in Journal of Autism & Developmental Disorders, June 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

blogs
1 blog

Citations

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30 Dimensions

Readers on

mendeley
36 Mendeley
Title
Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders
Published in
Journal of Autism & Developmental Disorders, June 2011
DOI 10.1007/s10803-011-1314-x
Pubmed ID
Authors

Rabindra Tirouvanziam, Tetyana V. Obukhanych, Julie Laval, Pavel A. Aronov, Robin Libove, Arpita Goswami Banerjee, Karen J. Parker, Ruth O’Hara, Leonard A. Herzenberg, Leonore A. Herzenberg, Antonio Y. Hardan

Abstract

The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 19%
Student > Master 7 19%
Other 6 17%
Unspecified 4 11%
Researcher 4 11%
Other 8 22%
Readers by discipline Count As %
Medicine and Dentistry 12 33%
Agricultural and Biological Sciences 7 19%
Psychology 4 11%
Unspecified 4 11%
Biochemistry, Genetics and Molecular Biology 2 6%
Other 7 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2011.
All research outputs
#2,680,905
of 12,316,253 outputs
Outputs from Journal of Autism & Developmental Disorders
#1,175
of 3,051 outputs
Outputs of similar age
#29,193
of 144,018 outputs
Outputs of similar age from Journal of Autism & Developmental Disorders
#23
of 49 outputs
Altmetric has tracked 12,316,253 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,051 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 144,018 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.