Title |
The dynorphin/κ-opioid receptor system and its role in psychiatric disorders
|
---|---|
Published in |
Cellular and Molecular Life Sciences, October 2011
|
DOI | 10.1007/s00018-011-0844-x |
Pubmed ID | |
Authors |
H. A. Tejeda, T. S. Shippenberg, R. Henriksson |
Abstract |
The dynorphin/κ-opioid receptor system has been implicated in the pathogenesis and pathophysiology of several psychiatric disorders. In the present review, we present evidence indicating a key role for this system in modulating neurotransmission in brain circuits that subserve mood, motivation, and cognitive function. We overview the pharmacology, signaling, post-translational, post-transcriptional, transcriptional, epigenetic and cis regulation of the dynorphin/κ-opioid receptor system, and critically review functional neuroanatomical, neurochemical, and pharmacological evidence, suggesting that alterations in this system may contribute to affective disorders, drug addiction, and schizophrenia. We also overview the dynorphin/κ-opioid receptor system in the genetics of psychiatric disorders and discuss implications of the reviewed material for therapeutics development. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Spain | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 125 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 18% |
Researcher | 18 | 14% |
Student > Master | 14 | 11% |
Student > Bachelor | 10 | 8% |
Other | 8 | 6% |
Other | 26 | 20% |
Unknown | 30 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 22 | 17% |
Agricultural and Biological Sciences | 20 | 16% |
Medicine and Dentistry | 17 | 13% |
Psychology | 16 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
Other | 15 | 12% |
Unknown | 32 | 25% |